Entry Detail

General Information

Database ID: LDA0004730
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:BBOX1-AS1
Full Name:BBOX1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):27047186End Site(bp):27220113
External Links:
Ensembl ID:ENSG00000254560
Ensembl Transcript ID:N/A
Entrez Gene:103695435.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Primary Ovarian Insufficiency  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pituitary Neoplasms  (Score: 0.731059)
lung squamous cell carcinoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3829D010911
Disease Name:pituitary adenomaPituitary Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pituitary gland benign neoplasm that derives_from glandular epithelial cells.Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Alias:adenoma of the Pituitary glandPituitary Neoplasms//Neoplasm, Pituitary//Neoplasms, Pituitary//Pituitary Neoplasm//Pituitary Tumors//Pituitary Tumor//Tumor, Pituitary//Tumors, Pituitary//Pituitary Adenoma//Adenoma, Pituitary//Adenomas, Pituitary//Pituitary Adenomas//Pituitary Carcinoma//Carcinoma, Pituitary//Carcinomas, Pituitary//Pituitary Carcinomas//Cancer of the Pituitary//Pituitary Cancer//Cancer, Pituitary//Cancers, Pituitary//Cancer of Pituitary//Pituitary Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:336   
More Information
Causal ncRNA Number:32
Network:
Top Causal ncRNAs:
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01004  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
CASC11  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
RPSAP52  (Score: 0.731059)
circVPS13C  (Score: 0.731059)
SNHG6  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35324526
Disease Name:Pituitary Neoplasms
Sample:pituitary adenoma tissues and cells
Dysfunction Pattern:Interaction(miR-361-3p/E2F1 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Description: The expression of BBOX1-AS1 in pituitary adenoma tissues and cells has been increased, according to our findings. We identify BBOX1-AS1 bind to miR-361-3p and to suppress its expression in a negative way. Moreover, miR-361-3p has been shown to bind with E2F1 and inhibit its expression. E2F1 also corrected miR-361-3p-mediated cell invasion, proliferation and apoptosis in BBOX1-AS1-dysregulated pituitary adenoma cells in rescue tests.
Causality:Yes
Causal Description:Furthermore, it is also noted that downregulation of BBOX1-AS1causes the inhibition of pituitary adenoma cells which result in invasion, apoptosis and proliferation, as well as boosting tumor development in vivo . In addition, BBOX1-AS1 knockdown inhibited tumor development in vivo .
Clinical-realted Application: