Entry Detail

General Information

Database ID: LDA0004734
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:BCYRN1
Full Name:brain cytoplasmic RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:BC200|BC200a|LINC00004|NCRNA00004
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):47335315End Site(bp):47335514
External Links:
Ensembl ID:ENSG00000236824
Ensembl Transcript ID:N/A
Entrez Gene:618.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Glioma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Glioma  (Score: 0.985791)
Myelodysplastic Syndromes  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//migration assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32104095
Disease Name:Glioma
Sample:
Dysfunction Pattern:regulation[miR-125a-5p]
Validated Method:qRT-PCR//Wound Healing Assay//Transwell Assay
Description: Mechanistically, upregulated expression of BCYRN1 in glioma acts as a sponge to sequester the endogenous tumor suppressor miR-125a-5p and to further increase the expression TAZ.
Causality:Yes
Causal Description:The upregulation of BCYRN1 promoted the proliferation, migration and invasion of glioma cells.
Clinical-realted Application:

[2] PubMed ID:32978519
Disease Name:Glioma
Sample:glioma tissues
Dysfunction Pattern:regulation[PTEN/AKT/p21 pathway]
Validated Method:RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//migration assay//Colony Formation Assay
Description:Among them, BCYRN1 was the most downregulated lncRNA, and its low expression positively correlated with glioma progression. BCYRN1 functioned as a ceRNA to inhibit glioma progression by sponging miR-619-5p to regulate CUEDC2 expression and PTEN/AKT/p21 pathway.
Causality:Yes
Causal Description: Functionally, BCYRN1 overexpression inhibited cell proliferation, migration in glioma cell lines, whereas BCYRN1 depletion resulted in the opposite way.
Clinical-realted Application: