Entry Detail

General Information

Database ID: LDA0004741
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:BCYRN1
Full Name:brain cytoplasmic RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:BC200|BC200a|LINC00004|NCRNA00004
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):47335315End Site(bp):47335514
External Links:
Ensembl ID:ENSG00000236824
Ensembl Transcript ID:N/A
Entrez Gene:618.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Glioma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Glioma  (Score: 0.985791)
Myelodysplastic Syndromes  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050908D009190
Disease Name:myelodysplastic syndromeMyelodysplastic Syndromes
Category:Disease OntologyMeSH
Type:Hemic and Lymphatic Diseases
Define:A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets.Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Alias:Myelodysplastic Syndromes//Myelodysplastic Syndrome//Syndrome, Myelodysplastic//Syndromes, Myelodysplastic//Dysmyelopoietic Syndromes//Dysmyelopoietic Syndrome//Syndrome, Dysmyelopoietic//Syndromes, Dysmyelopoietic//Hematopoetic Myelodysplasia//Hematopoetic Myelodysplasias//Myelodysplasia, Hematopoetic//Myelodysplasias, Hematopoetic

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
BCYRN1  (Score: 0.731059)
BCYRN1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:35136029
Disease Name:Myelodysplastic Syndromes
Sample:MDS patients, MDS cells
Dysfunction Pattern:Interaction(LncRNA BC200/miR-150-5p/MYB )
Validated Method:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining//ChIP
Description:we found that BC200 was highly expressed in MDS patients compared with normal individuals. Mechanistic investigations revealed that BC200 functioned as a miRNA sponge to positively regulate the expression of MYB through sponging miR-150-5p and subsequently promoted malignant proliferation of MDS cells. Conversely, we found that BC200 was a direct transcriptional target of MYB, and knockdown of MYB abolished the oncogenic effect of BC200/miR-150-5p.
Causality:Yes
Causal Description:Knockdown of BC200 inhibited MDS cell proliferation, colony formation, and cell cycle progression in vitro and suppressed the growth and invasiveness of MDS cells in vivo.
Clinical-realted Application: