Entry Detail

General Information

Database ID: LDA0004747
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MANCR
Full Name:mitotically associated long non coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00704
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):4650185End Site(bp):4678070
External Links:
Ensembl ID:ENSG00000231298
Ensembl Transcript ID:N/A
Entrez Gene:100216001.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Lymphoma, Mantle-Cell  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Thyroid Carcinoma, Anaplastic  (Score: 0.731059)
esophageal carcinoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Lymphoma, Mantle-Cell  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Thyroid Carcinoma, Anaplastic  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080522D065646
Disease Name:thyroid gland anaplastic carcinomaThyroid Carcinoma, Anaplastic
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thyroid gland carcinoma that is composed of undifferentiated cells.An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.
Alias:anaplastic thyroid carcinomaThyroid Carcinoma, Anaplastic//Anaplastic Thyroid Carcinoma//Anaplastic Thyroid Carcinomas//Carcinoma, Anaplastic Thyroid//Carcinomas, Anaplastic Thyroid//Thyroid Carcinomas, Anaplastic//Thyroid Cancer, Anaplastic//Anaplastic Thyroid Cancer//Anaplastic Thyroid Cancers//Cancer, Anaplastic Thyroid//Cancers, Anaplastic Thyroid//Thyroid Cancers, Anaplastic

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.985791)
UCA1  (Score: 0.985791)
HOTAIRM1  (Score: 0.731059)
HCP5  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP-AS1  (Score: 0.731059)
MANCR  (Score: 0.731059)
HOTAIRM1  (Score: 0.731059)
HCP5  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33178758
Disease Name:Thyroid Carcinoma, Anaplastic
Sample:ATC tissues,cell lines
Dysfunction Pattern:Expression[highly expressed]
Validated Method:CCK8//qRT-PCR//Transwell Assay
Description:One of the lncRNAs, mitotically associated long non-coding RNA (MANCR; LINC00704), was significantly overexpressed in ATC cell lines and patient samples compared with NT and papillary thyroid cancer (PTC).
Causality:Yes
Causal Description: MANCR depletion in ATC cells significantly inhibited cancer cell proliferation and invasion, and induced apoptosis.
Clinical-realted Application: