Entry Detail

General Information

Database ID: LDA0004762
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SGO1-AS1
Full Name:SGO1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:SGOL1-AS1
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):20174286End Site(bp):20186115
External Links:
Ensembl ID:ENSG00000231304
Ensembl Transcript ID:N/A
Entrez Gene:100874028.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Leukemia, Myeloid, Acute  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5517
Disease Name:stomach carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach cancer that is located_in the stomach.
Alias:cancer of the stomach//carcinoma of stomach//gastric carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:60   
More Information
Causal ncRNA Number:52
Network:
Top Causal ncRNAs:
GASAL1  (Score: 0.985791)
GASAL1  (Score: 0.985791)
lnc-LIFR-AS1  (Score: 0.731059)
circPRRX1  (Score: 0.731059)
hsa_circ_0000592  (Score: 0.731059)
SGO1-AS1  (Score: 0.731059)
BCYRN1  (Score: 0.731059)
CASC2  (Score: 0.731059)
LIFR-AS1  (Score: 0.731059)
HEIH  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//ISH//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:34706749
Disease Name:stomach carcinoma
Sample:gastric carcinoma tissues
Dysfunction Pattern:Interaction(TGFB1/2/PTBP1 )
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//ISH//Transfection//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Microarray//Cell Proliferation Assay//ChIP
Description:SGO1-AS1 was downregulated in gastric carcinoma tissues compared to adjacent normal tissues, and its downregulation was positively correlated with advanced clinical stage, metastasis status and poor patient prognosis. Mechanistically, SGO1-AS1 facilitated TGFB1/2 mRNA decay by competitively binding the PTBP1 protein, resulting in reduced TGFβ production and, thus, preventing the epithelial-to-mesenchymal transition (EMT) and metastasis. In addition, in turn, TGFβ inhibited SGO1-AS1 transcription by inducing ZEB1.
Causality:Yes
Causal Description:The functional experiments revealed that SGO1-AS1 inhibited GC cell invasion and metastasis in vitro and in vivo.
Clinical-realted Application: