Entry Detail

General Information

Database ID: LDA0004769
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SLCO4A1
Full Name:solute carrier organic anion transporter family member 4A1
Category:LncRNA
Species:Homo sapiens
Synonyms:OATP-E|OATP1|OATP4A1|OATPE|OATPRP1|POAT|SLC21A12
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):62642503End Site(bp):62690740
External Links:
Ensembl ID:ENSG00000101187
Ensembl Transcript ID:N/A
Entrez Gene:28231.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Mucocutaneous Lymph Node Syndrome  (Score: 0.731059)
Mucocutaneous Lymph Node Syndrome  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:13378D009080
Disease Name:Kawasaki diseaseMucocutaneous Lymph Node Syndrome
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities.An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
Alias:Kawasaki's disease//MLNS//acute febrile MCLS//acute febrile mucocutaneous lymph node syndrome//mucocutaneous lymph node syndromeMucocutaneous Lymph Node Syndrome//Kawasaki Syndrome//Lymph Node Syndrome, Mucocutaneous//Kawasaki Disease

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
SLCO4A1  (Score: 0.731059)
SOCS2-AS1  (Score: 0.731059)
hsa_circ_3302  (Score: 0.731059)
SLCO4A1  (Score: 0.731059)
SOCS2-AS1  (Score: 0.731059)
hsa_circ_3302  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:35282018
Disease Name:Mucocutaneous Lymph Node Syndrome
Sample: serum of KD patients, HUVECs
Dysfunction Pattern:Interaction(miR-335-5p/POU5F1 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA//Bioinformatics Analysis
Description:LncRNA Slco4a1 was significantly upregulated in the serum of KD patients compared with healthy controls. LncRNA Slco4a1 was upregulated in human umbilical vein endothelial cells (HUVECs) stimulated with KD serum.lncRNA Slco4a1 is a sponge of miR-335-5p and negatively regulated the expression of miR-335-5p. POU5F1 was the downstream target of miR-335-5p, and miR-335-5p overexpression could upregulate the expression of POU5F1.
Causality:Yes
Causal Description:LncRNA Slco4a1 overexpression could promote the expression of inflammatory factors and apoptosis in HUVECs. The number of inflammatory cells and the infiltration area of the coronary artery in KD rats were decreased after lncRNA Slco4a1 silencing.
Clinical-realted Application: