Entry Detail

General Information

Database ID: LDA0004803
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SCIRT
Full Name:stem cell inhibitory RNA transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DATOC-1
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):43995723End Site(bp):44074652
External Links:
Ensembl ID:ENSG00000237686
Ensembl Transcript ID:N/A
Entrez Gene:101929705.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Lung Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Atherosclerosis  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Atherosclerosis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1936D050197
Disease Name:atherosclerosisAtherosclerosis
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Alias:Atherosclerosis//Atheroscleroses//Atherogenesis//Atherogeneses

 

Disease Association Statistics

Total Associated ncRNA Number:206   
More Information
Causal ncRNA Number:96
Network:
Top Causal ncRNAs:
XIST  (Score: 0.999893)
H19  (Score: 0.999893)
XIST  (Score: 0.999893)
H19  (Score: 0.999893)
MIAT  (Score: 0.985791)
TUG1  (Score: 0.985791)
MIAT  (Score: 0.985791)
PVT1  (Score: 0.985791)
TUG1  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:BrdU//qRT-PCR//Transfection//RNA Pull-Down
Weak Evidence:

 

Reference

[1] PubMed ID:34742341
Disease Name:Atherosclerosis
Sample:HAOSMCs
Dysfunction Pattern:Regulation(miR-146a)
Validated Method:BrdU//qRT-PCR//Transfection//RNA Pull-Down
Description:SCIRT was downregulated by atherosclerosis, while miR-146a was upregulated by atherosclerosis. SCIRT was detected in both cytoplasm and nuclear samples, and it directly interacted with miR-146a. In HAOSMCs, overexpression of SCIRT and miR-146a did not affect the expression of each other. Interestingly, SCIRT suppressed the proliferation of HAOSMCs and reduced the enhancing effects of miR-146a on cell proliferation.
Causality:Yes
Causal Description:In HAOSMCs, overexpression of SCIRT and miR-146a did not affect the expression of each other.
Clinical-realted Application: