Entry Detail

General Information

Database ID: LDA0004806
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SEMA3B
Full Name:semaphorin 3B
Category:LncRNA
Species:Homo sapiens
Synonyms:LUCA-1|SEMA5|SEMAA|SemA|semaV
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):50267652End Site(bp):50277546
External Links:
Ensembl ID:ENSG00000012171
Ensembl Transcript ID:N/A
Entrez Gene:7869.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Glioblastoma  (Score: 0.731059)
gastric cardia adenocarcinoma  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
gastric cardia adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6271
Disease Name:gastric cardia adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:
Alias:adenocarcinoma of Cardia of stomach

 

Disease Association Statistics

Total Associated ncRNA Number:8   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
LINC01503  (Score: 0.731059)
SEMA3B  (Score: 0.731059)
SEMA3B-AS1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
LINC01503  (Score: 0.731059)
SEMA3B  (Score: 0.731059)
SEMA3B-AS1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//IHC//RNA Pull-Down//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30656427
Disease Name:gastric cardia adenocarcinoma
Sample:GCA tissues,cell lines
Dysfunction Pattern:Interaction[ZNF143 ]
Validated Method:qRT-PCR//RNA Pull-Down//IHC//Western Blot
Description:Frequent downregulation of SEMA3B, SEMA3B-AS1, and miR-6872 was detected in GCA tissues and gastric cancer cells. ZNF143 might be the target gene of miR-6872-5p and miR-6872-5p functioning synergistically with SEMA3B to suppress cell invasion.
Causality:Yes
Causal Description:Overexpression of SEMA3B and SEMA3B-AS1 inhibited gastric cancer cell proliferation, migration, and invasion in vitro.
Clinical-realted Application: