Entry Detail

General Information

Database ID: LDA0004815
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SERPINB9P1
Full Name:serpin family B member 9 pseudogene 1
Category:LncRNA
Species:Homo sapiens
Synonyms:SERPINB9P
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):2854657End Site(bp):2876510
External Links:
Ensembl ID:ENSG00000230438
Ensembl Transcript ID:N/A
Entrez Gene:221756.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Ischemic Stroke  (Score: 0.731059)
Ischemic Stroke  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000083242
Disease Name:Ischemic Stroke
Category:MeSH
Type:Nervous System Diseases
Define:Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin.
Alias:Ischemic Stroke//Ischemic Strokes//Stroke, Ischemic//Ischaemic Stroke//Ischaemic Strokes//Stroke, Ischaemic//Cryptogenic Ischemic Stroke//Cryptogenic Ischemic Strokes//Ischemic Stroke, Cryptogenic//Stroke, Cryptogenic Ischemic//Cryptogenic Stroke//Cryptogenic Strokes//Stroke, Cryptogenic//Cryptogenic Embolism Stroke//Cryptogenic Embolism Strokes//Embolism Stroke, Cryptogenic//Stroke, Cryptogenic Embolism//Wake-up Stroke//Stroke, Wake-up//Wake up Stroke//Wake-up Strokes//Acute Ischemic Stroke//Acute Ischemic Strokes//Ischemic Stroke, Acute//Stroke, Acute Ischemic

 

Disease Association Statistics

Total Associated ncRNA Number:84   
More Information
Causal ncRNA Number:40
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.985791)
PVT1  (Score: 0.985791)
CASC15  (Score: 0.731059)
Pvt1  (Score: 0.731059)
SNHG15  (Score: 0.731059)
SERPINB9P1  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
Gm12610  (Score: 0.731059)
Cdc14a  (Score: 0.731059)
U90926  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:34273050
Disease Name:Ischemic Stroke
Sample:patients with IS
Dysfunction Pattern:Mutation(rs375556 )
Validated Method:qRT-PCR//Genotyping
Description:We found that the SERPINB9P1 expression was significantly downregulated in patients with IS compared with that in healthy controls. After stratification by gender, the rs375556 polymorphism was significantly associated with susceptibility to female IS in the recessive model, and the significant association remained after adjusting for age.
Causality:Yes
Causal Description:After adjusting for gender and age, rs318429 was significantly associated with FPG and D-D levels, and rs375556 was significantly associated with INR and PTA levels in IS cases. Besides, the lncRNA SERPINB9P1 expressed downregulated in OGD/reoxygenation-treated human A172 cells. In conclusion, the lncRNA SERPINB9P1 may protect against cerebral ischemia-reperfusion injury and neurological impairment after IS.
Clinical-realted Application: