Entry Detail

General Information

Database ID: LDA0004820
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SENCR
Full Name:smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA
Category:LncRNA
Species:Homo sapiens
Synonyms:FLI1-AS1|lncRNA9
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):128691672End Site(bp):128696023
External Links:
Ensembl ID:ENSG00000254703
Ensembl Transcript ID:N/A
Entrez Gene:100507392.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Aortic Aneurysm, Abdominal  (Score: 0.731059)
Coronary Disease  (Score: 0.731059)
Aortic Aneurysm, Abdominal  (Score: 0.731059)
Coronary Disease  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7693D017544
Disease Name:abdominal aortic aneurysmAortic Aneurysm, Abdominal
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An aortic aneurysm that is located_in the abdominal aorta.An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
Alias:AORTIC ANEURYSM, FAMILIAL ABDOMINAL 1Aortic Aneurysm, Abdominal//Abdominal Aortic Aneurysms//Aneurysm, Abdominal Aortic//Abdominal Aortic Aneurysm//Abdominal Aorta Aneurysm//Abdominal Aorta Aneurysms//Aorta Aneurysm, Abdominal//Aneurysm, Abdominal Aorta

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:22
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.731059)
H20  (Score: 0.731059)
Gas5  (Score: 0.731059)
SENCR  (Score: 0.731059)
SBF2-AS1  (Score: 0.731059)
RBM33  (Score: 0.731059)
SNHG5  (Score: 0.731059)
TP53COR1  (Score: 0.731059)
hsa_circ_0087352  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//qRT-PCR//Transfection//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:32903173
Disease Name:Aortic Aneurysm, Abdominal
Sample:VSMCs & aortic tissues
Dysfunction Pattern:Expression(lower expressed)
Validated Method:In Vivo Experiment//qRT-PCR//Transfection//Western Blot
Description:SENCR was decreased in AAA. Overexpression of SENCR inhibited AAA formation via inhibition of VSMC apoptosis and extracellular matrix degradation.
Causality:Yes
Causal Description:Overexpression of SENCR inhibited AAA formation via inhibition of VSMC apoptosis and extracellular matrix degradation.
Clinical-realted Application: