Entry Detail

General Information

Database ID: LDA0004836
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG1
Full Name:small nucleolar RNA host gene 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00057|NCRNA00057|U22HG|UHG|lncRNA16
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):62851978End Site(bp):62855885
External Links:
Ensembl ID:ENSG00000255717
Ensembl Transcript ID:N/A
Entrez Gene:23642.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:82   
More Information
Causal Disease Number:74
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Stomach Neoplasms  (Score: 1)
Urinary Bladder Neoplasms  (Score: 1)
Urinary Bladder Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050866
Disease Name:oral squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:An oral cavity cancer that has_material_basis_in squamous cells.
Alias:mouth squamous cell carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
SNHG1  (Score: 0.731059)
SNHG1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Migration Assay//Transection//qRT-PCR//CCK8//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35281530
Disease Name:oral squamous cell carcinoma
Sample:OSCC samples and cells
Dysfunction Pattern:Interaction(SNHG1/miR-145-5p/KLF5 Axis)
Validated Method:Migration Assay//Transection//qRT-PCR//CCK8//Luciferase Report Assay//EdU Staining//Transwell Assay
Description:SNHG1 was abnormally upregulated in OSCC samples and linked to a poor prognosis of OSCC patients. miR-145-5p was a key downstream target inducing the oncogenic role of SNHG1 in the OSCC process with KLF5 as its downstream gene. SNHG1/miR-145-5p/KLF1 axis is responsible for driving the malignant process of OSCC.
Causality:Yes
Causal Description: Serving as an oncogene, SNHG1 strengthened proliferative and migratory functions of Tca8113 and CAL-27 cells.
Clinical-realted Application:SNHG1 was abnormally upregulated in OSCC samples and linked to a poor prognosis of OSCC patients.