Entry Detail

General Information

Database ID: LDA0004859
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG1
Full Name:small nucleolar RNA host gene 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00057|NCRNA00057|U22HG|UHG|lncRNA16
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):62851978End Site(bp):62855885
External Links:
Ensembl ID:ENSG00000255717
Ensembl Transcript ID:N/A
Entrez Gene:23642.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:82   
More Information
Causal Disease Number:74
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Stomach Neoplasms  (Score: 1)
Urinary Bladder Neoplasms  (Score: 1)
Urinary Bladder Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007822
Disease Name:Laryngeal Neoplasms
Category:MeSH
Type:Neoplasms
Define:Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Alias:Laryngeal Neoplasms//Neoplasms, Laryngeal//Laryngeal Neoplasm//Neoplasm, Laryngeal//Larynx Neoplasms//Larynx Neoplasm//Neoplasm, Larynx//Neoplasms, Larynx//Cancer of Larynx//Larynx Cancers//Laryngeal Cancer//Cancer, Laryngeal//Cancers, Laryngeal//Laryngeal Cancers//Larynx Cancer//Cancer, Larynx//Cancers, Larynx//Cancer of the Larynx

 

Disease Association Statistics

Total Associated ncRNA Number:44   
More Information
Causal ncRNA Number:40
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
PCAT19  (Score: 0.731059)
circRANBP9  (Score: 0.731059)
PCAT1  (Score: 0.731059)
SBF2-AS1  (Score: 0.731059)
CYTOR  (Score: 0.731059)
LINC00888  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31378897
Disease Name:Laryngeal Neoplasms
Sample:LC tissues
Dysfunction Pattern:Regulation[Notch1 signaling pathway]
Validated Method:CCK8//qRT-PCR//Western Blot
Description:SNHG1 was upregulated in LC tissues than that of controls. Besides, its level was higher in LC with T3-T4 relative to those of T1-T2.Notch1 overexpression could reverse the regulatory effects of SNHG1 on viability and proliferation of LC cells.
Causality:Yes
Causal Description:Knockdown of SNHG1 in Tu212 and Hep2 cells downregulated relative levels of Notch1 and Hes1. Moreover, SNHG1 knockdown resulted in decreased viability and proliferative ability of LC cells.
Clinical-realted Application:SNHG1 was upregulated in LC tissues than that of controls. Besides, its level was higher in LC with T3-T4 relative to those of T1-T2. Higher abundance of SNHG1 was identified in LC patients with lymph node metastasis compared with those non-metastatic patients. Survival analysis indicated that LC patients with high-level SNHG1 had worse overall survival.