Entry Detail

General Information

Database ID: LDA0004864
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SMARCA5
Full Name:SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Category:LncRNA
Species:Homo sapiens
Synonyms:ISWI|SNF2H|WCRF135|hISWI|hSNF2H
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):143513702End Site(bp):143557486
External Links:
Ensembl ID:ENSG00000153147
Ensembl Transcript ID:N/A
Entrez Gene:8467.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Cholangiocarcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4928D018281
Disease Name:intrahepatic cholangiocarcinomaCholangiocarcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree.A malignant tumor arising from the epithelium of the BILE DUCTS.
Alias:Intrahepatic bile duct carcinoma//peripheral CholangiocarcinomaCholangiocarcinoma//Cholangiocarcinomas//Cholangiocellular Carcinoma//Carcinoma, Cholangiocellular//Carcinomas, Cholangiocellular//Cholangiocellular Carcinomas//Extrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Extrahepatic//Cholangiocarcinomas, Extrahepatic//Extrahepatic Cholangiocarcinomas//Intrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Intrahepatic//Cholangiocarcinomas, Intrahepatic//Intrahepatic Cholangiocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:144
Network:
Top Causal ncRNAs:
NNT-AS1  (Score: 0.999893)
NNT-AS1  (Score: 0.999893)
SNHG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
NEAT1  (Score: 0.985791)
TTN-AS1  (Score: 0.985791)
SNHG1  (Score: 0.985791)
AGAP2-AS1  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31880360
Disease Name:Cholangiocarcinoma
Sample:ICC tissues
Dysfunction Pattern:Expression[lower expressed]
Validated Method:qRT-PCR
Description:Circ-SMARCA5 expression was reduced in ICC tumor tissues compared to adjacent tissues.
Causality:Yes
Causal Description:In TFK-1 and HuH-28 ICC cells, circ-SMARCA5 upregulation decreased cell proliferation, reduced relative cell viability in cisplatin-treated as well as gemcitabine-treated cells, and also decreased inhibitory concentration by 50% value (IC50 ) of cisplatin and gemcitabine.
Clinical-realted Application:Tumor circ-SMARCA5 high expression was negatively associated with Eastern Cooperative Oncology Group performance score, T stage, N stage, TNM stage, and abnormal CA199 status. Furthermore, OS was increased in patients with tumor circ-SMARCA5 high expression compared with those with low expression, and further multivariate Cox's regression demonstrated that tumor circ-SMARCA5 high expression was an independent predictive factor for longer OS.