| [1] PubMed ID: | 29337109 |
| Disease Name: | Stomach Neoplasms |
| Sample: | gastric cancer cells |
| Dysfunction Pattern: | Interaction(SMARCC2/miR-551b-3p/TMPRSS4 axis ) |
| Validated Method: | Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay |
| Description: | LncRNA SMARCC2 inhibits the expression of miR-551b-3p through binding to its mRNA response elements in gastric cancer cells. TMPRSS4 is a direct target gene of miR-551b-3p. We conclude that miR-551b-3p functions as a tumour suppressor gene in gastric cancer, and its function is regulated by LncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis. |
| Causality: | Yes |
| Causal Description: | Overexpression of LncRNA SMARCC2 enhances the proliferation and migration of gastric cancer cells, while inhibition of LncRNA SMARCC2 does the opposite. |
| Clinical-realted Application: | |
| [2] PubMed ID: | 31308753 |
| Disease Name: | Stomach Neoplasms |
| Sample: | blood |
| Dysfunction Pattern: | Expression[highly expressed] |
| Validated Method: | qRT-PCR |
| Description: | Compared with healthy subjects, the levels of plasma lncRNAs PANDAR, FOXD2-AS1, and SMARCC2 were all significantly higher in gastric cancer patients (P<0.05). |
| Causality: | No |
| Causal Description: | |
| Clinical-realted Application: | These lncRNAs were significantly associated with clinicopathological parameters of gastric cancer, like pathological differentiation, TNM stage, and/or lymph nodes metastasis, and/or invasion depth (P<0.05). The AUC for lncRNA PANDAR was 0.767, for FOXD2-AS1 was 0.700, for SMARCC2 was 0.748, and the AUC of the combinative diagnostic value of these three lncRNAs was 0.839. Adjusted by other variables, these lncRNAs' expressions were significantly associated with gastric cancer. |
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