Entry Detail

General Information

Database ID: LDA0004985
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SCARNA10
Full Name:small Cajal body-specific RNA 10
Category:LncRNA
Species:Homo sapiens
Synonyms:MBI|U85|lnc
Chromosome:12
Strand:+
Coordinate:
Start Site(bp):6510222End Site(bp):6510551
External Links:
Ensembl ID:ENSG00000239002
Ensembl Transcript ID:N/A
Entrez Gene:692148.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Liver Cirrhosis  (Score: 0.731059)
Liver Cirrhosis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D008103
Disease Name:Liver Cirrhosis
Category:MeSH
Type:Digestive System Diseases
Define:Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Alias:Liver Cirrhosis//Hepatic Cirrhosis//Cirrhosis, Hepatic//Cirrhosis, Liver//Fibrosis, Liver//Liver Fibrosis

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
lnc-ADD3-AS1  (Score: 0.731059)
CREBBP  (Score: 0.731059)
SCARNA10  (Score: 0.731059)
circFBXW4  (Score: 0.731059)
MBI‑52  (Score: 0.731059)
NEAT1  (Score: 0.731059)
lnc-ADD3-AS1  (Score: 0.731059)
CREBBP  (Score: 0.731059)
SCARNA10  (Score: 0.731059)
circFBXW4  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RIP//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:31281502
Disease Name:Liver Cirrhosis
Sample:liver tissues,blood
Dysfunction Pattern:Interaction[ ECM and TGFβ pathway]
Validated Method:RIP//ChIP
Description:It was found lncRNA ENSMUST00000158992, named as Scarna10, was remarkably up-regulated in mouse fibrotic livers according to the microarray data. We observed that the transcript of SCARNA10 was increased in the serum and liver from patients with advanced hepatic fibrosis.Mechanistically, RNA immunoprecipitation (RIP) assays demonstrated that SCARNA10 physically associated with polycomb repressive complex 2 (PRC2). Additionally, our results demonstrated that SCARNA10 functioned as a novel positive regulator of TGFβ signaling in hepatic fibrogenesis by inhibiting the binding of PRC2 to the promoters of the genes associated with ECM and TGFβ pathway, thus promoting the transcription of these genes.
Causality:Yes
Causal Description: Furthermore, we found that SCARNA10 promoted liver fibrosis both in vitro and in vivo through inducing hepatocytes (HCs) apoptosis and HSCs activation.
Clinical-realted Application: