Entry Detail

General Information

Database ID: LDA0004998
Species: Homo sapiens
Confidence Score: 0.548294
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SAMMSON
Full Name:survival associated mitochondrial melanoma specific oncogenic non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01212
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):69999744End Site(bp):70015301
External Links:
Ensembl ID:ENSG00000240405
Ensembl Transcript ID:N/A
Entrez Gene:101927152.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Uveal melanoma  (Score: 0.548294)
Uveal melanoma  (Score: 0.548294)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6039C536494
Disease Name:uveal melanomaUveal melanoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uveal cancer that has_material_basis_in uvea pigment cells.A melanoma that originates from uveal MELANOCYTES and is the most common primary intraocular malignancy. Tumors consist of four cell types: epitheloid, intermediate, mixed, and spindle. Somatic mutations in BAP1, GNAQ, GNA11, EIF1AX, and SF3B1 genes have been identified. OMIM: 155720
Alias:melanoma of Uvea

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.985791)
PVT1  (Score: 0.985791)
GAS5  (Score: 0.731059)
LOC100132707  (Score: 0.731059)
CARD11  (Score: 0.731059)
hsa_circ_0119872  (Score: 0.731059)
SNHG7  (Score: 0.731059)
GAS5  (Score: 0.731059)
LOC100132707  (Score: 0.731059)
CARD11  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:
Weak Evidence:Bioinformatics Analysis

 

Reference

[1] PubMed ID:34508176
Disease Name:Uveal melanoma
Sample:uveal melanoma cell lines
Dysfunction Pattern:Regulation
Validated Method:Bioinformatics Analysis
Description:Antisense oligonucleotide (ASO)-mediated SAMMSON inhibition impaired the growth and viability of a genetically diverse panel of uveal melanoma cell lines. These effects were accompanied by an induction of apoptosis and were recapitulated in two uveal melanoma patient derived xenograft (PDX) models through subcutaneous ASO delivery.
Causality:Yes
Causal Description:Antisense oligonucleotide (ASO)-mediated SAMMSON inhibition impaired the growth and viability of a genetically diverse panel of uveal melanoma cell lines. These effects were accompanied by an induction of apoptosis and were recapitulated in two uveal melanoma patient derived xenograft (PDX) models through subcutaneous ASO delivery.
Clinical-realted Application: