Entry Detail

General Information

Database ID: LDA0005007
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SCAMP1
Full Name:secretory carrier membrane protein 1
Category:LncRNA
Species:Homo sapiens
Synonyms:SCAMP|SCAMP37
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):78360617End Site(bp):78480739
External Links:
Ensembl ID:ENSG00000085365
Ensembl Transcript ID:N/A
Entrez Gene:9522.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Renal Cell  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4467D002292
Disease Name:clear cell renal cell carcinomaCarcinoma, Renal Cell
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Alias:Clear cell carcinoma of kidney//clear cell kidney carcinoma//conventional (Clear cell) renal cell carcinoma//conventional renal cell carcinoma//renal clear cell carcinomaCarcinoma, Renal Cell//Carcinomas, Renal Cell//Renal Cell Carcinomas//Nephroid Carcinoma//Carcinoma, Nephroid//Nephroid Carcinomas//Adenocarcinoma Of Kidney//Adenocarcinoma Of Kidneys//Kidney, Adenocarcinoma Of//Renal Cell Carcinoma//Renal Cell Cancer//Cancer, Renal Cell//Renal Cell Cancers//Adenocarcinoma, Renal//Renal Adenocarcinoma//Renal Adenocarcinomas//Renal Carcinoma//Carcinoma, Renal//Renal Carcinomas//Adenocarcinoma, Renal Cell//Adenocarcinomas, Renal Cell//Renal Cell Adenocarcinoma//Renal Cell Adenocarcinomas//Chromophobe Renal Cell Carcinoma//Sarcomatoid Renal Cell Carcinoma//Papillary Renal Cell Carcinoma//Renal Cell Carcinoma, Papillary//Chromophil Renal Cell Carcinoma//Clear Cell Renal Cell Carcinoma//Grawitz Tumor//Tumor, Grawitz//Clear Cell Renal Carcinoma//Carcinoma, Hypernephroid//Hypernephroid Carcinoma//Hypernephroid Carcinomas//Hypernephroma//Hypernephromas//Collecting Duct Carcinoma (Kidney)//Carcinoma, Collecting Duct (Kidney)//Carcinomas, Collecting Duct (Kidney)//Collecting Duct Carcinomas (Kidney)//Collecting Duct Carcinoma of the Kidney//Renal Collecting Duct Carcinoma//Collecting Duct Carcinoma//Carcinoma, Collecting Duct//Carcinomas, Collecting Duct//Collecting Duct Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:458   
More Information
Causal ncRNA Number:316
Network:
Top Causal ncRNAs:
SNHG12  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
PVT1  (Score: 1)
PVT1  (Score: 1)
SNHG12  (Score: 1)
SNHG1  (Score: 0.999893)
SNHG1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
MIR4435-2HG  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31550675
Disease Name:Carcinoma, Renal Cell
Sample:RCC tissues and cell lines
Dysfunction Pattern:Interaction[miR-429]
Validated Method:RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay
Description:SCAMP1 was elevated in RCC cells and tumors.Then, miR-429 was identified as downstream effector for SCAMP1-mediated tumorigenesis under H2O2 treatment. Besides, miR-429 was downregulated in human clinical tumors. ZEB1 and JUN were both found to be involved in the role of miR-429 in RCC. More interestingly, autophagy obviously affected miR-429-modulated RCC tumorigenesis. Eventually, we also showed that SCAMP1 played an oncogenic role in vivo.
Causality:Yes
Causal Description:SCAMP1 depletion attenuated cell viability and promoted apoptosis under H2O2 treatment.
Clinical-realted Application: