Entry Detail

General Information

Database ID: LDA0005019
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RPPH1
Full Name:ribonuclease P RNA component H1
Category:LncRNA
Species:Homo sapiens
Synonyms:H1RNA|RPPH1-1
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):20343071End Site(bp):20343411
External Links:
Ensembl ID:ENSG00000277209
Ensembl Transcript ID:N/A
Entrez Gene:85495.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32831924
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC cell lines
Dysfunction Pattern:regulation[miR-326/WNT2B axis]
Validated Method:CCK8//qRT-PCR//Colony Formation Assay
Description:RPPH1 was significantly upregulated in NSCLC cell lines, compared with a normal lung epithelial cell line. In conclusion, RPPH1 promoted NSCLC progression and lung cancer cell resistance to CDDP through miR-326 and WNT2B.
Causality:Yes
Causal Description:Compared with the negative control, RPPH1 silencing significantly reduced the number of invading cells, increased E-cadherin expression and reduced vimentin protein expression.
Clinical-realted Application: Moreover, high RPPH1 expression was associated with poor overall survival and disease progression.