Entry Detail

General Information

Database ID: LDA0005030
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RPLP0P2
Full Name:ribosomal protein lateral stalk subunit P0 pseudogene 2
Category:LncRNA
Species:Homo sapiens
Synonyms:RPLP0L2|RPLP0_3_1146
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):61615036End Site(bp):61639449
External Links:
Ensembl ID:ENSG00000243742
Ensembl Transcript ID:N/A
Entrez Gene:113157.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33649783
Disease Name:Colorectal Neoplasms
Sample:CRC tissue
Dysfunction Pattern:Expression(highly expressed)
Validated Method:CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Invasion Assay
Description: The results demonstrated that the expression levels of RPLP0P2 were higher in CRC tissue compared with those in normal tissue, and RPLP0P2 was associated with prognosis.
Causality:Yes
Causal Description: RPLP0P2 knockdown significantly decreased cell colony formation, migration and invasion, and arrested CRC cells in the S phase to G2/M phase transition. Furthermore, apoptosis was significantly increased in CRC cells infected with the RPLP0P2 shRNA lentivirus compared with in the control group.
Clinical-realted Application:. The results demonstrated that the expression levels of RPLP0P2 were higher in CRC tissue compared with those in normal tissue, and RPLP0P2 was associated with prognosis.