Entry Detail

General Information

Database ID: LDA0005037
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RUBCNL
Full Name:rubicon like autophagy enhancer
Category:LncRNA
Species:Homo sapiens
Synonyms:C13orf18|KIAA0226L|PACER
Chromosome:13
Strand:-
Coordinate:
Start Site(bp):46334681End Site(bp):46390042
External Links:
Ensembl ID:ENSG00000102445
Ensembl Transcript ID:N/A
Entrez Gene:80183.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.731059)
Pulmonary Disease, Chronic Obstructive  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Pulmonary Disease, Chronic Obstructive  (Score: 0.731059)
Mycoplasma Pneumoniae-Induced Inflammatory  (Score: 0.548294)
Mycoplasma Pneumoniae-Induced Inflammatory  (Score: 0.548294)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//qRT-PCR//FISH//MTT//Luciferase Report Assay//ELISA//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34316376
Disease Name:Colorectal Neoplasms
Sample:CRC tissues and cells
Dysfunction Pattern:regulation[NF-κB pathway ]
Validated Method:Western Blot//Wound Healing Assay//qRT-PCR//FISH//MTT//Luciferase Report Assay//ELISA//Colony Formation Assay//Transwell Assay
Description: RT-qPCR analysis revealed that PACER was highly expressed in CRC tissues and cells, and a high PACER-expression level was associated with poor prognosis.PACER modulates COX-2 expression through the nuclear factor kappa B (NF-κB) pathway in CRC.
Causality:Yes
Causal Description:MTT assay, wound-healing assay, colony-formation assay, and transwell assay revealed that PACER enhanced CRC-cell proliferation, invasion, and metastasis in vitro. Mouse xenograft models of CRC revealed that PACER promoted colorectal tumorigenesis in vivo.
Clinical-realted Application: RT-qPCR analysis revealed that PACER was highly expressed in CRC tissues and cells, and a high PACER-expression level was associated with poor prognosis.