Entry Detail

General Information

Database ID: LDA0005073
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG17
Full Name:small nucleolar RNA host gene 17
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):38420588End Site(bp):38435377
External Links:
Ensembl ID:ENSG00000196756
Ensembl Transcript ID:N/A
Entrez Gene:388796.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:36
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Ovarian Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Adenocarcinoma of Lung  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1993D012004
Disease Name:rectum cancerRectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A colorectal cancer that is located_in the rectum.Tumors or cancer of the RECTUM.
Alias:carcinoma of rectum//carcinoma of the rectum//malignant Rectal tumor//malignant neoplasm of rectum//malignant rectum tumor//malignant tumor of rectum//rectal cancerRectal Neoplasms//Neoplasm, Rectal//Rectal Neoplasm//Rectum Neoplasms//Neoplasm, Rectum//Rectum Neoplasm//Rectal Tumors//Rectal Tumor//Tumor, Rectal//Neoplasms, Rectal//Cancer of Rectum//Rectum Cancers//Rectal Cancer//Cancer, Rectal//Rectal Cancers//Rectum Cancer//Cancer, Rectum//Cancer of the Rectum

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
FEZF1-AS1  (Score: 0.731059)
SNHG17  (Score: 0.731059)
circTUBGCP3  (Score: 0.731059)
NKILA  (Score: 0.731059)
FEZF1-AS1  (Score: 0.731059)
SNHG17  (Score: 0.731059)
circTUBGCP3  (Score: 0.731059)
NKILA  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34249085
Disease Name:Rectal Neoplasms
Sample:rectal cancer tissues and cells
Dysfunction Pattern:Interaction(miR-361-3p/STC2 Axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Bioinformatics Analysis
Description:The upregulation status of SNHG17 was identified in rectal cancer tissues and cells. Furthermore, we showed that microRNA-361-3p (miR-361-3p) has decreased expression in tumor tissues and cells, and SNHG17 functions as a sponge for miR-361-3p.
Causality:Yes
Causal Description:Functionally, knockdown the expression of SNHG17 inhibits rectal cancer cell proliferation via stimulating cell apoptosis. In vivo assay showed that the knockdown of SNHG17 inhibits tumor growth.
Clinical-realted Application: