Entry Detail

General Information

Database ID: LDA0005081
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG16
Full Name:small nucleolar RNA host gene 16
Category:LncRNA
Species:Homo sapiens
Synonyms:ELNAT1|Nbla10727|Nbla12061|ncRAN
Chromosome:17
Strand:+
Coordinate:
Start Site(bp):76557764End Site(bp):76565348
External Links:
Ensembl ID:ENSG00000163597
Ensembl Transcript ID:N/A
Entrez Gene:100507246.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:70   
More Information
Causal Disease Number:60
Network:
Top Causal Diseases:
Neuroblastoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Neuroblastoma  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8947D003930
Disease Name:diabetic retinopathyDiabetic Retinopathy
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Alias:Retinal abnormality - diabetes-relatedDiabetic Retinopathy//Diabetic Retinopathies//Retinopathies, Diabetic//Retinopathy, Diabetic

 

Disease Association Statistics

Total Associated ncRNA Number:34   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
ZNF503-AS1  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
FLG-AS1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
LINC00673  (Score: 0.731059)
SNHG16  (Score: 0.731059)
VEAL2  (Score: 0.731059)
MAP4K2  (Score: 0.731059)
TDRG1  (Score: 0.731059)
SNHG7  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Tube Formation Assay//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33898104
Disease Name:Diabetic Retinopathy
Sample:hRMECs
Dysfunction Pattern:Interaction(microRNA (miR)-146a-5p and miR-7-5p/IRAK1/IRS1)
Validated Method:RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA//Transwell Assay
Description:We found that SNHG16 expression was significantly upregulated in hRMECs treated with HG. Moreover, SNHG16 was associated with nuclear factor κB (NF-κB) and phosphatidylinositol 3-kinase (PI3K)/AKT pathways. Mechanistically, SNHG16 could promote hRMEC dysfunction by sequestering microRNA (miR)-146a-5p and miR-7-5p to act as a competing endogenous RNA (ceRNA) with interleukin-1 receptor-associated kinase 1 (IRAK1) and insulin receptor substrate 1 (IRS1).
Causality:Yes
Causal Description:Functionally, SNHG16 could facilitate hRMEC proliferation, migration, and angiogenesis.
Clinical-realted Application: