Entry Detail


General Information

Database ID: LDA0005086
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG16
Full Name:small nucleolar RNA host gene 16
Category:LncRNA
Species:Homo sapiens
Synonyms:ELNAT1|Nbla10727|Nbla12061|ncRAN
Chromosome:17
Strand:+
Coordinate:
Start Site(bp):76557764End Site(bp):76565348
External Links:
Ensembl ID:ENSG00000163597
Ensembl Transcript ID:N/A
Entrez Gene:100507246.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:70   
More Information
Causal Disease Number:60
Network:
Top Causal Diseases:
Neuroblastoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Neuroblastoma  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:552D011014
Disease Name:pneumoniaPneumonia
Category:Disease OntologyMeSH
Type:Infections
Define:A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.Infection of the lung often accompanied by inflammation.
Alias:acute pneumoniaPneumonia//Pneumonias//Lobar Pneumonia//Lobar Pneumonias//Pneumonias, Lobar//Pneumonia, Lobar//Experimental Lung Inflammation//Experimental Lung Inflammations//Inflammation, Experimental Lung//Lung Inflammation, Experimental//Lung Inflammations, Experimental//Pneumonitis//Pneumonitides//Pulmonary Inflammation//Inflammation, Pulmonary//Inflammations, Pulmonary//Pulmonary Inflammations//Lung Inflammation//Inflammation, Lung//Inflammations, Lung//Lung Inflammations

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
CASC9  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0026579  (Score: 0.731059)
hsa_circ_0038467  (Score: 0.731059)
CASC9  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0026579  (Score: 0.731059)
hsa_circ_0038467  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//ELISA//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:31841752
Disease Name:pneumonia
Sample:blood
Dysfunction Pattern:Regulation[miR-370-3p/IGF2 axis]
Validated Method:CCK8//qRT-PCR//ELISA//RIP
Description:SNHG16 and IGF2 were upregulated while miR-370-3p was downregulated in serum of acute pneumonia patients and LPS-induced A549 cells. SNHG16 impeded cell viability and promoted apoptosis, inflammatory injury by targeting IGF2 mediated by miR-370-3p in LPS-induced A549 cells.
Causality:Yes
Causal Description:SNHG16 regulated proliferation, apoptosis and inflammatory cytokines by inhibiting miR-370-3p in LPS-induced A549 cells.
Clinical-realted Application: