Entry Detail

General Information

Database ID: LDA0005096
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG16
Full Name:small nucleolar RNA host gene 16
Category:LncRNA
Species:Homo sapiens
Synonyms:ELNAT1|Nbla10727|Nbla12061|ncRAN
Chromosome:17
Strand:+
Coordinate:
Start Site(bp):76557764End Site(bp):76565348
External Links:
Ensembl ID:ENSG00000163597
Ensembl Transcript ID:N/A
Entrez Gene:100507246.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:70   
More Information
Causal Disease Number:60
Network:
Top Causal Diseases:
Neuroblastoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Neuroblastoma  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4481D065631
Disease Name:allergic rhinitisRhinitis, Allergic
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.An inflammation of the NASAL MUCOSA triggered by ALLERGENS.
Alias:Non-seasonal allergic rhinitis//Perenial allergic rhinitis//atopic rhinitis//hay fever//pollenosis//seasonal allergic rhinitisRhinitis, Allergic//Allergic Rhinitides//Rhinitides, Allergic//Allergic Rhinitis

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
HCP5  (Score: 0.731059)
FR215775  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0067835  (Score: 0.731059)
HCP5  (Score: 0.731059)
FR215775  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34407675
Disease Name:Rhinitis, Allergic
Sample:AR tissues
Dysfunction Pattern:Interaction(miR-106b-5p/LIF JAK1/STAT3 pathway)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//IF
Description:RT-qPCR results showed that the expression of SNHG16 in AR was up-regulated. In conclusion, SNHG16 up-regulates LIF expression by binding with miR-106b-5p, thus promoting the activity of JAK1/STAT3 pathway, and promoting the development of AR. These results provide new targets for the treatment of AR and may help reduce the damage caused by AR.
Causality:Yes
Causal Description:The results showed that SNHG16 promoted cell apoptosis and inflammation.
Clinical-realted Application: