Entry Detail

General Information

Database ID: LDA0005097
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG16
Full Name:small nucleolar RNA host gene 16
Category:LncRNA
Species:Homo sapiens
Synonyms:ELNAT1|Nbla10727|Nbla12061|ncRAN
Chromosome:17
Strand:+
Coordinate:
Start Site(bp):76557764End Site(bp):76565348
External Links:
Ensembl ID:ENSG00000163597
Ensembl Transcript ID:N/A
Entrez Gene:100507246.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:70   
More Information
Causal Disease Number:60
Network:
Top Causal Diseases:
Neuroblastoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Neuroblastoma  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4074
Disease Name:pancreatic adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
Alias:pancreas adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
CCHE1  (Score: 0.731059)
circMYBL2  (Score: 0.731059)
LINC01139  (Score: 0.731059)
LINC01857  (Score: 0.731059)
LINC00857  (Score: 0.731059)
lnc-IUR  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:33435953
Disease Name:pancreatic adenocarcinoma
Sample:PC tissues and cell lines
Dysfunction Pattern:Interaction(miR-302b-3p/SLC2A4 axis)
Validated Method:qRT-PCR//Luciferase Report Assay//Western Blot
Description:SNHG16 expression was significantly elevated in PC tissues and cell lines and was associated with poor prognosis of PC patients.Knockdown of SNHG16 reduced PC cell proliferation, migration and invasion. SNHG16 acted as a sponge to regulate miR-302b-3p expression in PC cells. In addition, miR-302b-3p targeted SLC2A4 directly.
Causality:Yes
Causal Description:Knockdown of SNHG16 reduced PC cell proliferation, migration and invasion. SNHG16 acted as a sponge to regulate miR-302b-3p expression in PC cells. In addition, miR-302b-3p targeted SLC2A4 directly.
Clinical-realted Application:SNHG16 expression was significantly elevated in PC tissues and cell lines and was associated with poor prognosis of PC patients.