Entry Detail

General Information

Database ID: LDA0005139
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG3
Full Name:small nucleolar RNA host gene 3
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00014|RNU17C|RNU17D|U17HG|U17HG-A|U17HG-AB
Chromosome:1
Strand:+
Coordinate:
Start Site(bp):28505943End Site(bp):28510892
External Links:
Ensembl ID:ENSG00000242125
Ensembl Transcript ID:N/A
Entrez Gene:8420.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:44   
More Information
Causal Disease Number:42
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2600
Disease Name:laryngeal carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A larynx cancer that has_material_basis_in epithelial cells.
Alias:cancer of larynx//carcinoma of larynx

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
FOXD2-AS1  (Score: 0.731059)
WTAPP1  (Score: 0.731059)
SNHG3  (Score: 0.731059)
circABCB10  (Score: 0.731059)
CASC9  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
LINC01303  (Score: 0.731059)
LINC00886  (Score: 0.731059)
MALAT1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31238052
Disease Name:laryngeal carcinoma
Sample:LC tissues and cell lines
Dysfunction Pattern:Regulation[miR-384/WEE1 axis]
Validated Method:qRT-PCR//Luciferase Report Assay
Description:Our results showed increased SNHG3 in LC tissues and cell lines.Collectively, our results indicate that SNHG3 regulated LC cell migration and invasion via the miR-384/WEE1 axis.
Causality:Yes
Causal Description: Loss of function of SNHG3 reduced cell viability, migration, and invasion of TU212 and TU686 cells.
Clinical-realted Application: