Entry Detail

General Information

Database ID: LDA0005189
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG12
Full Name:small nucleolar RNA host gene 12
Category:LncRNA
Species:Homo sapiens
Synonyms:ASLNC04080|C1orf79|LINC00100|NCRNA00100|PNAS-123
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):28578538End Site(bp):28582983
External Links:
Ensembl ID:ENSG00000197989
Ensembl Transcript ID:N/A
Entrez Gene:85028.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:50   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Carcinoma, Renal Cell  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Stomach Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Glioma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3744
Disease Name:cervical squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A cervix carcinoma that has_material_basis_in squamous cells of the cervix.
Alias:squamous cell carcinoma of cervix//squamous cell carcinoma of the Cervix Uteri

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:50
Network:
Top Causal ncRNAs:
MCM3AP-AS1  (Score: 0.985791)
MCM3AP-AS1  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
SLC16A1-AS1  (Score: 0.731059)
GATA6-AS  (Score: 0.731059)
BLACAT1  (Score: 0.731059)
CASC9-1  (Score: 0.731059)
DGUOK-AS1  (Score: 0.731059)
MACC1-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31943193
Disease Name:cervical squamous cell carcinoma
Sample:CSCC tissues
Dysfunction Pattern:regulation[ERK/Slug pathway]
Validated Method:qRT-PCR
Description:We found that SNHG12 was significantly overexpressed in CSCC tissues. In addition, SNHG12 could facilitate epithelial-mesenchymal transition through ERK/Slug/E-cadherin pathway at least in part.
Causality:Yes
Causal Description:Functional experiments suggested that SNHG12 knockdown dramatically repressed CSCC cells proliferation, migration, and invasion while induced apoptosis in vitro as well as suppressed tumor growth in vivo.
Clinical-realted Application: