Entry Detail

General Information

Database ID: LDA0005265
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG12
Full Name:small nucleolar RNA host gene 12
Category:LncRNA
Species:Homo sapiens
Synonyms:ASLNC04080|C1orf79|LINC00100|NCRNA00100|PNAS-123
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):28578538End Site(bp):28582983
External Links:
Ensembl ID:ENSG00000197989
Ensembl Transcript ID:N/A
Entrez Gene:85028.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:50   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Carcinoma, Renal Cell  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Stomach Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Glioma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1936D050197
Disease Name:atherosclerosisAtherosclerosis
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Alias:Atherosclerosis//Atheroscleroses//Atherogenesis//Atherogeneses

 

Disease Association Statistics

Total Associated ncRNA Number:206   
More Information
Causal ncRNA Number:96
Network:
Top Causal ncRNAs:
XIST  (Score: 0.999893)
H19  (Score: 0.999893)
XIST  (Score: 0.999893)
H19  (Score: 0.999893)
MIAT  (Score: 0.985791)
TUG1  (Score: 0.985791)
MIAT  (Score: 0.985791)
PVT1  (Score: 0.985791)
TUG1  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:34313533
Disease Name:Atherosclerosis
Sample:AS patients and HUVECs
Dysfunction Pattern:Interaction(miR-218-5p/IGF2 axis)
Validated Method:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA//Bioinformatics Analysis
Description: We found that SNHG12 and IGF2 expression levels were high and miR-218-5p expression levels were low in AS patients and ox-LDL-treated HUVECs. Overall, SNHG12 promotes the development of AS by the miR-218-5p/IGF2 axis.
Causality:Yes
Causal Description:SNHG12 depletion attenuated ox-LDL-induced injury in HUVECs, whereas miR-218-5p suppression partially abated this effect. Moreover, IGF2 overexpression prevented the alleviative role of miR-218-5p in ox-LDL-treated HUVECs. SNHG12 upregulated IGF2 expression by sponging miR-218-5p. More importantly, SNHG12 increased proinflammatory cytokine production and augmented atherosclerotic lesions in vivo.
Clinical-realted Application: