LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0005270
Species:	Homo sapiens
Confidence Score:	0.985791
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

SNHG14

Full Name:

small nucleolar RNA host gene 14

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

Chromosome:

Strand:

Coordinate:

Start Site(bp):

24823608

End Site(bp):

25419462

External Links:

Ensembl ID:	ENSG00000224078
Ensembl Transcript ID:	N/A
Entrez Gene:	104472715.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

38 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Carcinoma, Hepatocellular (Score: 1)

Carcinoma, Non-Small-Cell Lung (Score: 0.999893)

Lymphoma, Large B-Cell, Diffuse (Score: 0.985791)

Urinary Bladder Neoplasms (Score: 0.985791)

Lymphoma, Large B-Cell, Diffuse (Score: 0.985791)

Uterine Cervical Neoplasms (Score: 0.985791)

Endometrial Neoplasms (Score: 0.985791)

Colorectal Neoplasms (Score: 0.985791)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:0050745	D016403
Disease Name:	diffuse large B-cell lymphoma	Lymphoma, Large B-Cell, Diffuse
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body.	Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Alias:		Lymphoma, Large B-Cell, Diffuse//Lymphoma, Histiocytic//Histiocytic Lymphomas//Lymphoma, Large Lymphoid, Diffuse//Lymphoma, Histiocytic, Diffuse//Lymphoma, Large Cell, Diffuse//Lymphoma, Diffuse Large-Cell//Lymphoma, Diffuse Large Cell//Diffuse Large-Cell Lymphoma//Diffuse Large Cell Lymphoma//Diffuse Large-Cell Lymphomas//Diffuse, Large B-Cell, Lymphoma//Histiocytic Lymphoma//Histiocytic Lymphoma, Diffuse//Diffuse Histiocytic Lymphoma//Diffuse Histiocytic Lymphomas//Lymphoma, Diffuse Histiocytic//Large Lymphoid Lymphoma, Diffuse//Large-Cell Lymphoma, Diffuse//Large Cell Lymphoma, Diffuse//Diffuse Large B-Cell Lymphoma//Diffuse Large B Cell Lymphoma//Lymphoma, Large-Cell, Diffuse

Disease Association Statistics

Total Associated ncRNA Number:

58 More Information

Causal ncRNA Number:

Network:

Top Causal ncRNAs:

FIRRE (Score: 0.985791)

NEAT1 (Score: 0.985791)

SNHG14 (Score: 0.985791)

MALAT1 (Score: 0.985791)

FIRRE (Score: 0.985791)

NEAT1 (Score: 0.985791)

SNHG14 (Score: 0.985791)

MALAT1 (Score: 0.985791)

circPCBP2 (Score: 0.731059)

circAPC (Score: 0.731059)

More Information

Evidence Support

Strong Evidence:	Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

Reference

[1] PubMed ID:	31570691
Disease Name:	Lymphoma, Large B-Cell, Diffuse
Sample:	DLBCL tissues and cell lines
Dysfunction Pattern:	Interaction[SNHG14/miR-5590-3p/ZEB1 ]
Validated Method:	CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:	Results depicted that SNHG14 was upregulated in DLBCL and its depletion retarded proliferation, migration and epithelial-to-mesenchymal transition (EMT). In conclusion, we firstly showed that SNHG14/miR-5590-3p/ZEB1 positive feedback loop promoted diffuse large B cell lymphoma progression and immune evasion through regulating PD-1/PD-L1 checkpoint, indicating that targeting SNHG14 was a potential approach to improve the efficacy of immunotherapy in DLBCL.
Causality:	Yes
Causal Description:	Results depicted that SNHG14 was upregulated in DLBCL and its depletion retarded proliferation, migration and epithelial-to-mesenchymal transition (EMT).
Clinical-realted Application:

[2] PubMed ID:	33682607
Disease Name:	Lymphoma, Large B-Cell, Diffuse
Sample:	DLBCL tissues and cell line
Dysfunction Pattern:	Interaction(miR-152-3p)
Validated Method:	Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//RIP//Transwell Assay
Description:	The results showed that SNHG14 expression increased and miR-152-3p expression decreased in DLBCL tissues and cell lines, indicating a negative correlation between miR-152-3p and SNHG14 expression.Furthermore, both the immune escape and progression of DLBCL are advanced by SNHG14 expression via its interactions with miR-152-3p.
Causality:	Yes
Causal Description:	Moreover, SNHG14 was found to promote DLBCL growth, migration, and EMT-like processes in vitro, and directly inhibits miR-152-3p gene expression via sequestration of the miR-152-3p transcripts in DLBCL. Additionally, SNHG14/miR-152-3p inhibits apoptosis and promotes cell proliferation on cytotoxic T lymphocytes (CTLs) in DLBCL via the PD-1/PD-L1 checkpoint.
Clinical-realted Application:

LncRNADisease v3.0

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