Entry Detail


General Information

Database ID: LDA0005271
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG14
Full Name:small nucleolar RNA host gene 14
Category:LncRNA
Species:Homo sapiens
Synonyms:115HG|IC-SNURF-SNRPN|LNCAT|NCRNA00214|U-UBE3A-ATS|UBE3A-AS|UBE3A-AS1|UBE3A-ATS|UBE3AATS
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):24823608End Site(bp):25419462
External Links:
Ensembl ID:ENSG00000224078
Ensembl Transcript ID:N/A
Entrez Gene:104472715.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Endometrial Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10591D011225
Disease Name:pre-eclampsiaPre-Eclampsia
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Alias:gestational hypertension//hypertension induced by pregnancy//pre-eclamptic toxaemia//preeclampsia//preeclampsia/eclampsia//pregnancy associated hypertension//pregnancy toxemia//proteinuric hypertension of pregnancy//toxaemia of pregnancyPre-Eclampsia//Pre Eclampsia//Preeclampsia//Pregnancy Toxemias//Pregnancy Toxemia//Toxemia, Pregnancy//Edema-Proteinuria-Hypertension Gestosis//Edema Proteinuria Hypertension Gestosis//Gestosis, Edema-Proteinuria-Hypertension//Hypertension-Edema-Proteinuria Gestosis//Gestosis, Hypertension-Edema-Proteinuria//Hypertension Edema Proteinuria Gestosis//Toxemia Of Pregnancy//Of Pregnancies, Toxemia//Of Pregnancy, Toxemia//Pregnancies, Toxemia Of//Pregnancy, Toxemia Of//Toxemia Of Pregnancies//EPH Complex//EPH Toxemias//EPH Toxemia//Toxemia, EPH//Toxemias, EPH//EPH Gestosis//Gestosis, EPH//Toxemias, Pregnancy//Preeclampsia Eclampsia 1//1, Preeclampsia Eclampsia//1s, Preeclampsia Eclampsia//Eclampsia 1, Preeclampsia//Eclampsia 1s, Preeclampsia//Preeclampsia Eclampsia 1s//Proteinuria-Edema-Hypertension Gestosis//Gestosis, Proteinuria-Edema-Hypertension//Proteinuria Edema Hypertension Gestosis

 

Disease Association Statistics

Total Associated ncRNA Number:42   
More Information
Causal ncRNA Number:36
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
DLX6-AS1  (Score: 0.731059)
UCA1  (Score: 0.731059)
SNHG14  (Score: 0.731059)
APOA1-AS  (Score: 0.731059)
uc.187  (Score: 0.731059)
DANCR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay//Invasion Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:33161910
Disease Name:Pre-Eclampsia
Sample:PE patients
Dysfunction Pattern:Interaction(miR-330-5p)
Validated Method:Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//IF//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay//Transwell Assay
Description:lncRNA SNHG14 was downregulated in PE patients; it was involved in trophoblast proliferation and regulated cell proliferation during G1/S transition. Luciferase reporter assay indicated that lncRNA SNHG14 served as a molecular sponge for miR-330-5p and negatively regulated miR-330-5p expression in PE. Furthermore, the effects of silenced SNHG14 on trophoblast proliferation, migration, invasion and EMT were reversed by addition of miR-330-5p inhibitor, suggesting that in PE lncRNA SNHG14 functions by competitively binding to miR-330-5p.
Causality:Yes
Causal Description:lncRNA SNHG14 was downregulated in PE patients; it was involved in trophoblast proliferation and regulated cell proliferation during G1/S transition. In addition, lncRNA SNHG14 promoted migration, invasion and epithelial-mesenchymal transition (EMT) in HTR-8/SVneo cells.
Clinical-realted Application: