Entry Detail

General Information

Database ID: LDA0005272
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG14
Full Name:small nucleolar RNA host gene 14
Category:LncRNA
Species:Homo sapiens
Synonyms:115HG|IC-SNURF-SNRPN|LNCAT|NCRNA00214|U-UBE3A-ATS|UBE3A-AS|UBE3A-AS1|UBE3A-ATS|UBE3AATS
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):24823608End Site(bp):25419462
External Links:
Ensembl ID:ENSG00000224078
Ensembl Transcript ID:N/A
Entrez Gene:104472715.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Endometrial Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D058186
Disease Name:Acute Kidney Injury
Category:MeSH
Type:Urogenital Diseases
Define:Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Alias:Acute Kidney Injury//Acute Kidney Injuries//Kidney Injuries, Acute//Kidney Injury, Acute//Acute Renal Injury//Acute Renal Injuries//Renal Injuries, Acute//Renal Injury, Acute//Renal Insufficiency, Acute//Acute Renal Insufficiencies//Renal Insufficiencies, Acute//Acute Renal Insufficiency//Kidney Insufficiency, Acute//Acute Kidney Insufficiencies//Kidney Insufficiencies, Acute//Acute Kidney Insufficiency//Kidney Failure, Acute//Acute Kidney Failures//Kidney Failures, Acute//Acute Renal Failure//Acute Renal Failures//Renal Failures, Acute//Renal Failure, Acute//Acute Kidney Failure

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PVT1  (Score: 0.731059)
Kcnq1ot1  (Score: 0.731059)
H19  (Score: 0.731059)
CASC2  (Score: 0.731059)
SNHG14  (Score: 0.731059)
hsa_circ_0020339  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33505213
Disease Name:Acute Kidney Injury
Sample:HK-2 cells
Dysfunction Pattern:Interaction(miR-93/IRAK4 and IL-6R/NF-κB and STAT3 signaling)
Validated Method:Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//ChIP
Description:Increased expression of SNHG14 was observed in LPS-induced HK-2 cells, and this was due to the activation of the TLR4/NF-κB pathway. Further investigations confirmed that SNHG14 exerted the functions via miR-93 which could regulate the activation of NF-κB and STAT3 signaling by targeting IRAK4 and IL-6R.
Causality:Yes
Causal Description: In vitro studies showed that SNHG14 was involved in the oxidative stress, inflammation, and apoptosis of LPS-induced HK-2 cells.
Clinical-realted Application: