Entry Detail

General Information

Database ID: LDA0005295
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PELATON
Full Name:plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation
Category:LncRNA
Species:Homo sapiens
Synonyms:GCRL1|LINC01272|SMIM25
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):50267478End Site(bp):50279788
External Links:
Ensembl ID:ENSG00000224397
Ensembl Transcript ID:N/A
Entrez Gene:100506115.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Crohn Disease  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
glioblastoma  (Score: 0.731059)
Crohn Disease  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
glioblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8778D003424
Disease Name:Crohn's diseaseCrohn Disease
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:An intestinal disease that involves inflammation located_in intestine.A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Alias:Crohn disease//Crohn's disease of colon//Crohn's disease of large bowel//Granulomatous Colitis//Pediatric Crohn's diseaseCrohn Disease//Crohn's Enteritis//Regional Enteritis//Crohn's Disease//Crohns Disease//Inflammatory Bowel Disease 1//Enteritis, Granulomatous//Granulomatous Enteritis//Enteritis, Regional//Ileocolitis//Colitis, Granulomatous//Granulomatous Colitis//Ileitis, Terminal//Terminal Ileitis//Ileitis, Regional//Regional Ileitides//Regional Ileitis

 

Disease Association Statistics

Total Associated ncRNA Number:24   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
hsa_circ_102610  (Score: 0.985791)
hsa_circ_103124  (Score: 0.985791)
hsa_circ_102610  (Score: 0.985791)
hsa_circ_103124  (Score: 0.985791)
MALAT1  (Score: 0.731059)
PELATON  (Score: 0.731059)
hsa_circ_103765  (Score: 0.731059)
circGMCL1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
PELATON  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//IF//Luciferase Report Assay//H&E Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35559411
Disease Name:Crohn Disease
Sample:CD patient and cell line
Dysfunction Pattern:Interaction(miR-153-5p)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//Transwell Assay//IF
Description: LINC01272 was highly expressed in patients with CD. Knockdown of LINC01272 inhibited TGF-β1-induced epithelial-mesenchymal transition (EMT). Additionally, LINC01272 regulated TGF-β1-induced EMT through the miR-153-5p axis, and knockdown of LINC01272 inhibited EMT in CD mice in vivo.
Causality:Yes
Causal Description:Knockdown of LINC01272 inhibited TGF-β1-induced epithelial-mesenchymal transition (EMT). Additionally, LINC01272 regulated TGF-β1-induced EMT through the miR-153-5p axis, and knockdown of LINC01272 inhibited EMT in CD mice in vivo.
Clinical-realted Application: