LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0005297
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

PGM5-AS1

Full Name:

PGM5 antisense RNA 1

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

FAM233A

Chromosome:

Strand:

Coordinate:

Start Site(bp):

68355164

End Site(bp):

68357866

External Links:

Ensembl ID:	ENSG00000224958
Ensembl Transcript ID:	N/A
Entrez Gene:	572558.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

12 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Colorectal Neoplasms (Score: 1)

Esophageal Squamous Cell Carcinoma (Score: 0.985791)

Urinary Bladder Neoplasms (Score: 0.731059)

Osteosarcoma (Score: 0.731059)

Uterine Cervical Neoplasms (Score: 0.731059)

Urinary Bladder Neoplasms (Score: 0.731059)

Osteosarcoma (Score: 0.731059)

Uterine Cervical Neoplasms (Score: 0.731059)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:11054	D001749
Disease Name:	urinary bladder cancer	Urinary Bladder Neoplasms
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	An urinary system cancer that results_in malignant growth located_in the urinary bladder.	Tumors or cancer of the URINARY BLADDER.
Alias:	bladder cancer//tumor of the bladder	Urinary Bladder Neoplasms//Neoplasm, Urinary Bladder//Urinary Bladder Neoplasm//Bladder Tumors//Bladder Tumor//Tumor, Bladder//Tumors, Bladder//Neoplasms, Bladder//Bladder Neoplasms//Bladder Neoplasm//Neoplasm, Bladder//Urinary Bladder Cancer//Cancer, Urinary Bladder//Malignant Tumor of Urinary Bladder//Cancer of the Bladder//Bladder Cancer//Bladder Cancers//Cancer, Bladder//Cancer of Bladder

Disease Association Statistics

Total Associated ncRNA Number:

604 More Information

Causal ncRNA Number:

428

Network:

Top Causal ncRNAs:

SNHG1 (Score: 1)

TINCR (Score: 0.999893)

PCAT6 (Score: 0.999893)

GAS5 (Score: 0.999893)

MILIP (Score: 0.999893)

TUG1 (Score: 0.999893)

circCEP128 (Score: 0.999893)

XIST (Score: 0.999893)

CASC9 (Score: 0.999893)

More Information

Evidence Support

Strong Evidence:	qRT-PCR//Western Blot
Weak Evidence:

Reference

[1] PubMed ID:	36017912
Disease Name:	Urinary Bladder Neoplasms
Sample:	BC tissues and cells
Dysfunction Pattern:	Regulation(miR-587/SLIT3 Axis)
Validated Method:	qRT-PCR//Western Blot
Description:	PGM5-AS1 and SLIT3 were expressed at low levels in BC, whereas miR-587 exhibited the opposite trend. PGM5-AS1 overexpression significantly inhibited BC cell proliferation and migration, promoted apoptosis in vitro, and alleviated tumor growth in vivo. miR-587 has been shown to be a target of PGM5-AS1, and miR-587 overexpression can reverse the inhibitory effect of PGM5-AS1 upregulation on BC cell growth. Furthermore, miR-587 directly targeted SLIT3 and negatively regulated its expression. PGM5-AS1 inhibited BC cell proliferation and migration while facilitating apoptosis through the miR-587/SLIT3 pathway. PGM5-AS1 represses BC development via the miR-587/SLIT3 axis, indicating that PGM5-AS1 may be a candidate biomarker and target for BC treatment.
Causality:	Yes
Causal Description:	PGM5-AS1 overexpression significantly inhibited BC cell proliferation and migration, promoted apoptosis in vitro, and alleviated tumor growth in vivo.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail