Entry Detail

General Information

Database ID: LDA0005298
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PGM5-AS1
Full Name:PGM5 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:FAM233A
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):68355164End Site(bp):68357866
External Links:
Ensembl ID:ENSG00000224958
Ensembl Transcript ID:N/A
Entrez Gene:572558.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3347D012516
Disease Name:osteosarcomaOsteosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin.A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Alias:Osteogenic sarcoma//Skeletal sarcoma//bone tissue neoplasm//osteoid sarcomaOsteosarcoma//Osteosarcomas//Osteosarcoma Tumor//Osteosarcoma Tumors//Tumor, Osteosarcoma//Tumors, Osteosarcoma//Sarcoma, Osteogenic//Osteogenic Sarcomas//Sarcomas, Osteogenic//Osteogenic Sarcoma

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:600
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
PVT1  (Score: 1)
GAS5  (Score: 1)
SNHG16  (Score: 1)
LINC00662  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
LINC00662  (Score: 1)
ZFAS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:32412676
Disease Name:Osteosarcoma
Sample:osteosarcoma tissues
Dysfunction Pattern:regulation[miR-140-5p-mediated FBN1]
Validated Method:qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP
Description: Expression of PGM5-AS1, miR-140-5p, and FBN1 was altered by overexpression, shRNA, mimic, or inhibitors in order to investigate how they regulated migration, invasion, and EMT of osteosarcoma cells in vitro. Taken together, PGM5-AS1 depletion causes FBN1 reduction to retard osteosarcoma processes by negatively modulating miR-140-5p.
Causality:Yes
Causal Description:Loss- and gain-of-function approaches were employed in nude mice to detect their roles in tumorigenesis in vivo.
Clinical-realted Application: