Entry Detail

General Information

Database ID: LDA0005307
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PEG10
Full Name:paternally expressed 10
Category:LncRNA
Species:Homo sapiens
Synonyms:EDR|HB-1|MEF3L|Mar2|Mart2|RGAG3|RTL2|SIRH1
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):94656325End Site(bp):94669695
External Links:
Ensembl ID:ENSG00000242265
Ensembl Transcript ID:N/A
Entrez Gene:23089.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Glioma  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
Glioma  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050745D016403
Disease Name:diffuse large B-cell lymphomaLymphoma, Large B-Cell, Diffuse
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body.Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Alias:Lymphoma, Large B-Cell, Diffuse//Lymphoma, Histiocytic//Histiocytic Lymphomas//Lymphoma, Large Lymphoid, Diffuse//Lymphoma, Histiocytic, Diffuse//Lymphoma, Large Cell, Diffuse//Lymphoma, Diffuse Large-Cell//Lymphoma, Diffuse Large Cell//Diffuse Large-Cell Lymphoma//Diffuse Large Cell Lymphoma//Diffuse Large-Cell Lymphomas//Diffuse, Large B-Cell, Lymphoma//Histiocytic Lymphoma//Histiocytic Lymphoma, Diffuse//Diffuse Histiocytic Lymphoma//Diffuse Histiocytic Lymphomas//Lymphoma, Diffuse Histiocytic//Large Lymphoid Lymphoma, Diffuse//Large-Cell Lymphoma, Diffuse//Large Cell Lymphoma, Diffuse//Diffuse Large B-Cell Lymphoma//Diffuse Large B Cell Lymphoma//Lymphoma, Large-Cell, Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:58   
More Information
Causal ncRNA Number:54
Network:
Top Causal ncRNAs:
FIRRE  (Score: 0.985791)
NEAT1  (Score: 0.985791)
SNHG14  (Score: 0.985791)
MALAT1  (Score: 0.985791)
FIRRE  (Score: 0.985791)
NEAT1  (Score: 0.985791)
SNHG14  (Score: 0.985791)
MALAT1  (Score: 0.985791)
circPCBP2  (Score: 0.731059)
circAPC  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Flow Cytometry//qRT-PCR//MTT//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32976381
Disease Name:Lymphoma, Large B-Cell, Diffuse
Sample:DLBCL tissues and cells
Dysfunction Pattern:interaction[sponging miR-101-3p]
Validated Method:Flow Cytometry//qRT-PCR//MTT//Transwell Assay
Description: PEG10 and KIF2A level were significantly upregulated, while miR-101-3p was downregulated in DLBCL tissues and cells. Besides, miR-101-3p was a target of PEG10 and miR-101-3p could directly target KIF2A. PEG10 promoted KIF2A level by sponging miR-101-3p.
Causality:Yes
Causal Description:PEG10, or KIF2A deletion significantly inhibited the proliferative, migratory, and invasive abilities of DLBCL cells and elevated cell apoptosis in DLBCL cells.
Clinical-realted Application: