Entry Detail

General Information

Database ID: LDA0005310
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PDIA3P1
Full Name:protein disulfide isomerase family A member 3 pseudogene 1
Category:LncRNA
Species:Homo sapiens
Synonyms:ERp60|GRP58P|PDIA3P
Chromosome:1
Strand:+
Coordinate:
Start Site(bp):147177851End Site(bp):147179949
External Links:
Ensembl ID:ENSG00000180867
Ensembl Transcript ID:N/A
Entrez Gene:171423.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Invasion Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31572559
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues and the adjacent normal tissues
Dysfunction Pattern:Regulation[Wnt/β-catenin signaling ]
Validated Method:CCK8//qRT-PCR//Invasion Assay//Western Blot
Description:In the present study, PDIA3P expression in NSCLC tissues was examined. RT-qPCR analysis showed that PDIA3P expression was significantly higher in NSCLC tissues (Fig. 1A; P<0.05) compared with the control. The present study showed that lncRNA PDIA3P promoted NSCLC progression by regulating Wnt/β-catenin signaling, highlighting a potential therapeutic target for treating patients with NSCLC treatment.
Causality:Yes
Causal Description:Furthermore, functional assays suggested that PDIA3P inhibition significantly suppressed the proliferation and invasion of NSCLC cells in vitro and reduced tumor growth in vivo.
Clinical-realted Application: In the present study, it was demonstrated that lncRNA PDIAP3 expression was significantly increased in patients with NSCLC, particularly in patients with an advanced Tumor-Node-Metastasis stages and lymph-node metastasis. The Gene Expression Profiling Interactive Analysis database revealed that patients with NSCLC with high lncRNA PDIA3P expression had a poorer disease-free survival rate.