Entry Detail

General Information

Database ID: LDA0005329
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCED1B-AS1
Full Name:PCED1B antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):47208420End Site(bp):47216443
External Links:
Ensembl ID:ENSG00000247774
Ensembl Transcript ID:N/A
Entrez Gene:100233209.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.731059)
colorectal adenocarcinoma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
colorectal adenocarcinoma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050861
Disease Name:colorectal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A colorectal carcinoma that derives_from epithelial cells of glandular origin.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection
Weak Evidence:

 

Reference

[1] PubMed ID:35176937
Disease Name:colorectal adenocarcinoma
Sample:colorectal adenocarcinoma tissues and corresponding cell lines
Dysfunction Pattern:Regulation(miR-633/HOXA9 axis)
Validated Method:Transfection
Description:We found that PCED1B-AS1 was upregulated and miR-633 was downregulated in colorectal adenocarcinoma tissues and corresponding cell lines. Knockdown of PCED1B-AS1 inhibited cell proliferation and promoted apoptosis, while miR-633 inhibitor elevated proliferation and reduced apoptosis of cancer cell lines. In addition, overexpression of HOXA9 obviously attenuated the protective role of knockdown of PCED1B-AS1 or miR-633 mimics in colorectal adenocarcinoma progression. PCED1B-AS1 could negatively regulate the expression of HOXA9 by sponging miR-633. The in vivo experiments confirmed the role of PCED1B-AS1 and miR-633 in colorectal adenocarcinoma, as well as the regulatory relationship of this axis. Our results demonstrated that knockdown of PCED1B-AS1 inhibited the progression of colorectal adenocarcinoma by regulating the miR-633/HOXA9 axis.
Causality:Yes
Causal Description:Our results demonstrated that knockdown of PCED1B-AS1 inhibited the progression of colorectal adenocarcinoma by regulating the miR-633/HOXA9 axis.
Clinical-realted Application: