Entry Detail

General Information

Database ID: LDA0005338
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCBP2-OT1
Full Name:PCBP2 overlapping transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:TUC.338|TUC338|uc.338
Chromosome:12
Strand:+
Coordinate:
Start Site(bp):53464468End Site(bp):53465057
External Links:
Ensembl ID:ENSG00000282977
Ensembl Transcript ID:N/A
Entrez Gene:102157401.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Esophageal Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11054D001749
Disease Name:urinary bladder cancerUrinary Bladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An urinary system cancer that results_in malignant growth located_in the urinary bladder.Tumors or cancer of the URINARY BLADDER.
Alias:bladder cancer//tumor of the bladderUrinary Bladder Neoplasms//Neoplasm, Urinary Bladder//Urinary Bladder Neoplasm//Bladder Tumors//Bladder Tumor//Tumor, Bladder//Tumors, Bladder//Neoplasms, Bladder//Bladder Neoplasms//Bladder Neoplasm//Neoplasm, Bladder//Urinary Bladder Cancer//Cancer, Urinary Bladder//Malignant Tumor of Urinary Bladder//Cancer of the Bladder//Bladder Cancer//Bladder Cancers//Cancer, Bladder//Cancer of Bladder

 

Disease Association Statistics

Total Associated ncRNA Number:604   
More Information
Causal ncRNA Number:428
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
TINCR  (Score: 0.999893)
PCAT6  (Score: 0.999893)
GAS5  (Score: 0.999893)
MILIP  (Score: 0.999893)
TUG1  (Score: 0.999893)
circCEP128  (Score: 0.999893)
XIST  (Score: 0.999893)
CASC9  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31162712
Disease Name:Urinary Bladder Neoplasms
Sample:bladder cancer tissues
Dysfunction Pattern:Interaction[upregulating miR-10b]
Validated Method:qRT-PCR
Description:We found that TUC338 was upregulated in early-stage bladder cancer patients and showed early diagnostic values. After surgical resection, plasma levels of TUC338 were significantly downregulated. Bladder cancer cells with TUC338 overexpression showed upregulated miR-10b, while miR-10b overexpression failed to significantly affect TUC338.
Causality:Yes
Causal Description:TUC338 and miR-10b overexpression significantly promoted bladder cancer cell invasion and migration.
Clinical-realted Application: