Entry Detail

General Information

Database ID: LDA0005339
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCBP2-OT1
Full Name:PCBP2 overlapping transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:TUC.338|TUC338|uc.338
Chromosome:12
Strand:+
Coordinate:
Start Site(bp):53464468End Site(bp):53465057
External Links:
Ensembl ID:ENSG00000282977
Ensembl Transcript ID:N/A
Entrez Gene:102157401.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Esophageal Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10286
Disease Name:prostate carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Alias:cancer of prostate//carcinoma of prostate

 

Disease Association Statistics

Total Associated ncRNA Number:26   
More Information
Causal ncRNA Number:26
Network:
Top Causal ncRNAs:
PCBP2-OT1  (Score: 0.731059)
FGF14-AS2  (Score: 0.731059)
Erbb4-IR  (Score: 0.731059)
GAS5  (Score: 0.731059)
GASAL1  (Score: 0.731059)
BRE-AS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0102485  (Score: 0.731059)
MIR4435-2HG  (Score: 0.731059)
ZNF667-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31085276
Disease Name:prostate carcinoma
Sample:PC tissues
Dysfunction Pattern:Interaction[downregulatingmiR-466]
Validated Method:qRT-PCR//Transwell Assay
Description:It was observed that TUC338 was Expression[up-expression]regulated in tumor tissues comparing to adjacent healthy tissues of prostate carcinoma patients. TUC338 and miR-466 were inversely correlated in tumor tissues. miR-466 overexpression failed to affect TUC338 expression, while TUC338 overexpression led to downregulated miR-466 expression.
Causality:Yes
Causal Description:TUC338 overexpression failed to significantly affect cancer cell proliferation, but promoted cancer cell migration and invasion.
Clinical-realted Application:Plasma levels of TUC338 were also higher in prostate carcinoma patients than in healthy controls. A 5-year follow-Expression[up-expression] study showed that high plasma level of TUC338 was correlated with poor survival.