Entry Detail

General Information

Database ID: LDA0005340
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCBP1-AS1
Full Name:PCBP1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:Linc-GALH
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):69962263End Site(bp):70088208
External Links:
Ensembl ID:ENSG00000179818
Ensembl Transcript ID:N/A
Entrez Gene:400960.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
vulva squamous cell carcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
vulva squamous cell carcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2101
Disease Name:vulva squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A vulva carcinoma and has_material_basis_in squamous cells and is located_in the epidermis of the vulvar tissue.
Alias:Vulvar Epidermoid carcinoma//vulvar squamous cell carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
PCBP1-AS1  (Score: 0.731059)
PCBP1-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35116901
Disease Name:vulva squamous cell carcinoma
Sample:VSCC tissues and cells
Dysfunction Pattern:Interaction[TRAF5 and NF-κB]
Validated Method:CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay
Description: PCBP1-AS1 and TRAF5 mRNA expression were downregulated in VSCC tissues and were correlated with patient clinicopathological characteristics. As a tumor suppressor gene, PCBP1-AS1 regulates the proliferation and apoptosis of VSCC via TRAF5-mediated expression of the NF-κB.
Causality:Yes
Causal Description:Increase of PCBP1-AS1 significantly inhibited proliferation and enhanced apoptosis via TRAF5-mediated regulation of the NF-κB signaling pathway.
Clinical-realted Application: