Entry Detail

General Information

Database ID: LDA0005341
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCBP2-OT1
Full Name:PCBP2 overlapping transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:TUC.338|TUC338|uc.338
Chromosome:12
Strand:+
Coordinate:
Start Site(bp):53464468End Site(bp):53465057
External Links:
Ensembl ID:ENSG00000282977
Ensembl Transcript ID:N/A
Entrez Gene:102157401.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Esophageal Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D009303
Disease Name:Nasopharyngeal Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the NASOPHARYNX.
Alias:Nasopharyngeal Neoplasms//Nasopharyngeal Neoplasm//Neoplasm, Nasopharyngeal//Neoplasms, Nasopharyngeal//Nasopharynx Neoplasms//Nasopharynx Neoplasm//Neoplasm, Nasopharynx//Neoplasms, Nasopharynx//Cancer of Nasopharynx//Nasopharynx Cancers//Nasopharyngeal Cancer//Cancer, Nasopharyngeal//Cancers, Nasopharyngeal//Nasopharyngeal Cancers//Nasopharynx Cancer//Cancer, Nasopharynx//Cancers, Nasopharynx//Cancer of the Nasopharynx

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
HOTTIP  (Score: 0.731059)
hsa_circ_0000615  (Score: 0.731059)
PCBP2-OT1  (Score: 0.731059)
PVT1  (Score: 0.731059)
HOTTIP  (Score: 0.731059)
hsa_circ_0000615  (Score: 0.731059)
PCBP2-OT1  (Score: 0.731059)
PVT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//qPCR//Cell Cycle Assay//Luciferase Report Assay//Cell Proliferation Assay//IP
Weak Evidence:

 

Reference

[1] PubMed ID:36224455
Disease Name:Nasopharyngeal Neoplasms
Sample:NPC cells
Dysfunction Pattern:Interaction(miR-1226-3p/FGF2 axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//IP//Western Blot//qPCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay
Description: Higher level of TUC338 was also observed in NPC cells. Mechanistically, TUC338 acted as molecular sponge of miR-1226-3p and attenuated the negative regulation of miR-1226-3p on the expression of fibroblast growth factor 2 (FGF2).
Causality:Yes
Causal Description:Functional study indicated that down-regulated TUC338 remarkably suppressed the NPC cell proliferation and cell migration. Notably, depletion of TUC338 significantly inhibited the in vivo tumor growth.
Clinical-realted Application:Interestingly, NPC patients harboring overexpressed TUC338 have worse prognosis.