Entry Detail

General Information

Database ID: LDA0005378
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:POU3F3
Full Name:POU class 3 homeobox 3
Category:LncRNA
Species:Homo sapiens
Synonyms:BRN1|OTF8|SNIBFIS|brain-1|oct-8
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):104854115End Site(bp):104858574
External Links:
Ensembl ID:ENSG00000198914
Ensembl Transcript ID:N/A
Entrez Gene:5455.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Triple Negative Breast Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Melanoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4467D002292
Disease Name:clear cell renal cell carcinomaCarcinoma, Renal Cell
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Alias:Clear cell carcinoma of kidney//clear cell kidney carcinoma//conventional (Clear cell) renal cell carcinoma//conventional renal cell carcinoma//renal clear cell carcinomaCarcinoma, Renal Cell//Carcinomas, Renal Cell//Renal Cell Carcinomas//Nephroid Carcinoma//Carcinoma, Nephroid//Nephroid Carcinomas//Adenocarcinoma Of Kidney//Adenocarcinoma Of Kidneys//Kidney, Adenocarcinoma Of//Renal Cell Carcinoma//Renal Cell Cancer//Cancer, Renal Cell//Renal Cell Cancers//Adenocarcinoma, Renal//Renal Adenocarcinoma//Renal Adenocarcinomas//Renal Carcinoma//Carcinoma, Renal//Renal Carcinomas//Adenocarcinoma, Renal Cell//Adenocarcinomas, Renal Cell//Renal Cell Adenocarcinoma//Renal Cell Adenocarcinomas//Chromophobe Renal Cell Carcinoma//Sarcomatoid Renal Cell Carcinoma//Papillary Renal Cell Carcinoma//Renal Cell Carcinoma, Papillary//Chromophil Renal Cell Carcinoma//Clear Cell Renal Cell Carcinoma//Grawitz Tumor//Tumor, Grawitz//Clear Cell Renal Carcinoma//Carcinoma, Hypernephroid//Hypernephroid Carcinoma//Hypernephroid Carcinomas//Hypernephroma//Hypernephromas//Collecting Duct Carcinoma (Kidney)//Carcinoma, Collecting Duct (Kidney)//Carcinomas, Collecting Duct (Kidney)//Collecting Duct Carcinomas (Kidney)//Collecting Duct Carcinoma of the Kidney//Renal Collecting Duct Carcinoma//Collecting Duct Carcinoma//Carcinoma, Collecting Duct//Carcinomas, Collecting Duct//Collecting Duct Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:458   
More Information
Causal ncRNA Number:316
Network:
Top Causal ncRNAs:
SNHG12  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
PVT1  (Score: 1)
PVT1  (Score: 1)
SNHG12  (Score: 1)
SNHG1  (Score: 0.999893)
SNHG1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
MIR4435-2HG  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//CCK8//FISH//qRT-PCR//RIP//IF//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34352801
Disease Name:Carcinoma, Renal Cell
Sample:tumor tissues
Dysfunction Pattern:Regulation(LncRNA GAS5)
Validated Method:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay//IF
Description:In the present study, we found that POU3F3 was upregulated while GAS5 was downregulated in tumor tissues than that in adjacent healthy tissues of patients with RCC. In situ hybridization analysis showed that POU3F3 was mostly expressed in tumor tissues, while GAS5 was mostly expressed in adjacent healthy tissues. Overexpression of POU3F3 mediated the downregulation of GAS5 in RCC cells, while GAS5 overexpression failed to significantly affect POU3F3 expression. Overexpression of POU3F3 led to promoted, while GAS5 overexpression led to inhibited proliferation, migration, and invasion of RCC cells. In addition, GAS5 overexpression attenuated the enhancing effects of POU3F3 overexpression on cancer cell proliferation, migration, and invasion.
Causality:Yes
Causal Description: Overexpression of POU3F3 mediated the downregulation of GAS5 in RCC cells, while GAS5 overexpression failed to significantly affect POU3F3 expression. Overexpression of POU3F3 led to promoted, while GAS5 overexpression led to inhibited proliferation, migration, and invasion of RCC cells. In addition, GAS5 overexpression attenuated the enhancing effects of POU3F3 overexpression on cancer cell proliferation, migration, and invasion.
Clinical-realted Application:High level of POU3F3 and low level of GAS5 were closely correlated with poor prognosis of RCC patients. Expression levels of POU3F3 and GAS5 were significantly and inversely correlated in tumor tissues but not in adjacent healthy tissues of RCC patients.