Entry Detail

General Information

Database ID: LDA0005379
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:POU3F3
Full Name:POU class 3 homeobox 3
Category:LncRNA
Species:Homo sapiens
Synonyms:BRN1|OTF8|SNIBFIS|brain-1|oct-8
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):104854115End Site(bp):104858574
External Links:
Ensembl ID:ENSG00000198914
Ensembl Transcript ID:N/A
Entrez Gene:5455.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Triple Negative Breast Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Melanoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8398D010003
Disease Name:osteoarthritisOsteoarthritis
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that has_material_basis_in worn out cartilage located_in joint.A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Alias:Osteoarthrosis and allied disorder//degenerative arthritis//degenerative joint disease//hypertrophic arthritis//osteoarthrosisOsteoarthritis//Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans

 

Disease Association Statistics

Total Associated ncRNA Number:784   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
MCM3AP-AS1  (Score: 0.985791)
hsa_circ_0005567  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
XIST  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Flow Cytometry//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:35264092
Disease Name:Osteoarthritis
Sample:OA patients/animal cartilage tissues, chondrocyte model
Dysfunction Pattern:Interaction(miR-29a- 3p/FOXO3 Axis)
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//ELISA
Description:The expression level of POU3F3 was decreased in OA patients/animal cartilage tissues and IL-1β-stimulated in vitro chondrocyte model. Mechanistically, Luciferase reporter and RNA immunoprecipitation (RIP) assays indicated that miR-29a-3p could directly bind to POU3F3, and FOXO3 was a target gene of miR-29a-3p. Functional rescue assays confirmed this POU3F3/miR-29a-3p/FOXO3 axis in chondrocytes during OA occurrence.
Causality:Yes
Causal Description:POU3F3 overexpression inhibited IL-1β-induced injury of chondrocytes, enhancing cell viability, suppressing apoptosis and inflammatory cytokine secretion, rescuing metabolic dysfunction, and restraining autophagy in vitro. Furthermore, intraarticularly delivery of lentivirus containing POU3F3 alleviates the damage in mouse OA model in vivo.
Clinical-realted Application: