Entry Detail

General Information

Database ID: LDA0005395
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PICSAR
Full Name:P38 inhibited cutaneous squamous cell carcinoma associated lincRNA
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf113|LINC00162|NCRNA00162|NLC1-C|NLC1C|PRED74
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):44999208End Site(bp):45004727
External Links:
Ensembl ID:ENSG00000275874
Ensembl Transcript ID:N/A
Entrez Gene:378825.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Skin Neoplasms  (Score: 0.985791)
Skin Neoplasms  (Score: 0.985791)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3498
Disease Name:pancreatic ductal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
Alias:ductal adenocarcinoma of the pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:110
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
circMYOF  (Score: 0.731059)
circBFAR  (Score: 0.731059)
hsa_circ_000684  (Score: 0.731059)
circSLIT2  (Score: 0.731059)
hsa_circ_0005105  (Score: 0.731059)
circEYA3  (Score: 0.731059)
circNEIL3  (Score: 0.731059)
hsa_circ_0047744  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:32364285
Disease Name:pancreatic ductal adenocarcinoma
Sample:cell lines
Dysfunction Pattern:regulation[RelA/p65]
Validated Method:qRT-PCR//RNA-seq
Description: These data were validated in several PDAC cell lines, and significant upregulation of LINC00162 was found in all of them. Furthermore, the result of Chromatin immunoprecipitation assay revealed that RelA/p65 directly bound to LINC00162, and the expression of LINC00162 in PDAC decreased after RelA/p65 knock-down, the proliferation ability of AsPc-1 also significantly inhibited after knocking down LINC00162 and RelA/p65 simultaneously, indicating that RelA/p65 directly involve in the transcriptional regulation of LINC00162.
Causality:Yes
Causal Description:Knock-down of LINC00162 significantly inhibited the proliferation, colony formation and migration of PATC cells in vitro and suppressed the growth of PATC xenografts in vivo.
Clinical-realted Application: