Entry Detail

General Information

Database ID: LDA0005397
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PINK1-AS
Full Name:PINK1 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:NAPINK1|PINK1-AS1|PINK1AS
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):20642657End Site(bp):20652193
External Links:
Ensembl ID:ENSG00000117242
Ensembl Transcript ID:N/A
Entrez Gene:100861548.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Small Cell Lung Carcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Small Cell Lung Carcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D055752
Disease Name:Small Cell Lung Carcinoma
Category:MeSH
Type:Neoplasms
Define:A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Alias:Small Cell Lung Carcinoma//Small Cell Lung Cancer//Oat Cell Lung Cancer//Small Cell Cancer Of The Lung//Carcinoma, Small Cell Lung//Oat Cell Carcinoma of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:24
Network:
Top Causal ncRNAs:
circPVT1  (Score: 0.731059)
KCNQ1OT1  (Score: 0.731059)
LUADT1  (Score: 0.731059)
LINC01555  (Score: 0.731059)
LINC01116  (Score: 0.731059)
CASC11  (Score: 0.731059)
ZFPM2-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
NEF  (Score: 0.731059)
HIF1A-AS2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//qPCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35764723
Disease Name:Small Cell Lung Carcinoma
Sample:SCLC tissues
Dysfunction Pattern:Expression(highly expressed)
Validated Method:Transfection//qPCR//Transwell Assay
Description:We found that PINK1-AS was upregulated in SCLC tissues compared to that in non-cancer tissues. Plasma expression levels of PINK1-AS were increased in SCLC patients compared to that in the controls.
Causality:Yes
Causal Description:Moreover, PINK1-AS positively regulated the migration and invasion of SCLC cells.
Clinical-realted Application:High plasma expression levels of PINK1-AS were closely associated with worse survival. Plasma expression of PINK1-AS was only closely correlated with distant tumor metastasis, but not other factors. High plasma expression levels of PINK1-AS effectively separated patients with distant metastasis from non-metastatic patients.