Entry Detail

General Information

Database ID: LDA0005402
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PICSAR
Full Name:P38 inhibited cutaneous squamous cell carcinoma associated lincRNA
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf113|LINC00162|NCRNA00162|NLC1-C|NLC1C|PRED74
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):44999208End Site(bp):45004727
External Links:
Ensembl ID:ENSG00000275874
Ensembl Transcript ID:N/A
Entrez Gene:378825.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Skin Neoplasms  (Score: 0.985791)
Skin Neoplasms  (Score: 0.985791)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:HepatomaCarcinoma, Hepatocellular//Carcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Disease Association Statistics

Total Associated ncRNA Number:1438   
More Information
Causal ncRNA Number:1176
Network:
Top Causal ncRNAs:
LINC00467  (Score: 1)
SNHG6  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
DANCR  (Score: 1)
ST8SIA6-AS1  (Score: 1)
SNHG6  (Score: 1)
ZFPM2-AS1  (Score: 1)
CDKN2B-AS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Colony Formation Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:32860321
Disease Name:Carcinoma, Hepatocellular
Sample:HCC tissues and cells
Dysfunction Pattern:regulation[PI3K/AKT/mTOR signaling pathway]
Validated Method:IHC//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining
Description: In the present study, we found that PICSAR was upregulated in HCC tissues and cells and correlated with progression and poor prognosis in HCC patients.PICSAR played an oncogenic role by targeting miR-588 and subsequently promoted EIF6 expression and PI3K/AKT/mTOR activation in HCC.
Causality:Yes
Causal Description:Gain- and loss-of-function experiments indicated that PICSAR enhanced cell proliferation, colony formation, and cell cycle progression and inhibited apoptosis of HCC cells.
Clinical-realted Application: In the present study, we found that PICSAR was upregulated in HCC tissues and cells and correlated with progression and poor prognosis in HCC patients.