Entry Detail

General Information

Database ID: LDA0005403
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PICSAR
Full Name:P38 inhibited cutaneous squamous cell carcinoma associated lincRNA
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf113|LINC00162|NCRNA00162|NLC1-C|NLC1C|PRED74
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):44999208End Site(bp):45004727
External Links:
Ensembl ID:ENSG00000275874
Ensembl Transcript ID:N/A
Entrez Gene:378825.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Skin Neoplasms  (Score: 0.985791)
Skin Neoplasms  (Score: 0.985791)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11054D001749
Disease Name:urinary bladder cancerUrinary Bladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An urinary system cancer that results_in malignant growth located_in the urinary bladder.Tumors or cancer of the URINARY BLADDER.
Alias:bladder cancer//tumor of the bladderUrinary Bladder Neoplasms//Neoplasm, Urinary Bladder//Urinary Bladder Neoplasm//Bladder Tumors//Bladder Tumor//Tumor, Bladder//Tumors, Bladder//Neoplasms, Bladder//Bladder Neoplasms//Bladder Neoplasm//Neoplasm, Bladder//Urinary Bladder Cancer//Cancer, Urinary Bladder//Malignant Tumor of Urinary Bladder//Cancer of the Bladder//Bladder Cancer//Bladder Cancers//Cancer, Bladder//Cancer of Bladder

 

Disease Association Statistics

Total Associated ncRNA Number:604   
More Information
Causal ncRNA Number:428
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
TINCR  (Score: 0.999893)
PCAT6  (Score: 0.999893)
GAS5  (Score: 0.999893)
MILIP  (Score: 0.999893)
TUG1  (Score: 0.999893)
circCEP128  (Score: 0.999893)
XIST  (Score: 0.999893)
CASC9  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:Flow Cytometry//qRT-PCR//RNA Pull-Down//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:33344916
Disease Name:Urinary Bladder Neoplasms
Sample:bladder cancer cells and tissues
Dysfunction Pattern:interaction[binding THRAP3]
Validated Method:Flow Cytometry//qRT-PCR//RNA Pull-Down//RIP
Description:Here, we reported that LINC00162, a super-enhancer long noncoding RNA, was highly expressed in bladder cancer cells and tissues.Finally, we demonstrated a mechanism that LINC00162 could regulate PTTG1IP expression through binding THRAP3.
Causality:Yes
Causal Description: Knocking down LINC00162 expression can inhibit the proliferative activity of bladder cancer cells and the growth of transplanted tumors in vivo, while knocking down the expression of PTTG1IP could restore the proliferative activity of bladder cancer cells.
Clinical-realted Application: