An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.
Tumors or cancer of the SKIN.
Alias:
CA - skin cancer//malignant neoplasm of skin//melanoma and Non-melanoma skin cancer
Skin Neoplasms//Neoplasms, Skin//Neoplasm, Skin//Skin Neoplasm//Cancer of Skin//Skin Cancers//Cancer of the Skin//Skin Cancer//Cancer, Skin//Cancers, Skin
Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay
Description:
PICSAR was upregulated in CSCC tissues and cells.PICSAR knockdown suppressed cell proliferation and invasion and promoted apoptosis in CSCC cells by regulating miR-125b/YAP1 axis, providing new sights for treatment of CSCC.
Causality:
Yes
Causal Description:
PICSAR knockdown inhibited cell proliferation and invasion and induced apoptosis in CSCC cells.
The expression of PICSAR was upregulated in serum of cSCC patients and tumor tissues of patients.PICSAR expression was correlated with tumor size, grade of differentiation and TNM stages, and significantly increased in cSCC patients with poor tumor differentiation and cSCC patients with III-IV TNM stage.
Causality:
No
Causal Description:
Clinical-realted Application:
Additionally, serum PICSAR expression had relatively high diagnostic accuracy for the screening of cSCC. patients with high PICSAR expression had lower overall survival than the patients with low PICSAR expression, and PICSAR expression was an independent prognostic factors for cSCC patients.