Entry Detail

General Information

Database ID: LDA0005418
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PLA2G2C
Full Name:phospholipase A2 group IIC
Category:LncRNA
Species:Homo sapiens
Synonyms:UBXN10-AS1
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):20163055End Site(bp):20186518
External Links:
Ensembl ID:ENSG00000187980
Ensembl Transcript ID:N/A
Entrez Gene:391013.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Colonic Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:219D003110
Disease Name:colon cancerColonic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A colorectal cancer that is located_in the colon.Tumors or cancer of the COLON.
Alias:Colonic Neoplasms//Colonic Neoplasm//Neoplasm, Colonic//Neoplasms, Colonic//Colon Neoplasms//Colon Neoplasm//Neoplasm, Colon//Neoplasms, Colon//Cancer of Colon//Colon Cancers//Colon Cancer//Cancer, Colon//Cancers, Colon//Cancer of the Colon//Colonic Cancer//Cancer, Colonic//Cancers, Colonic//Colonic Cancers//Colon Adenocarcinoma//Adenocarcinoma, Colon//Adenocarcinomas, Colon//Colon Adenocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:272   
More Information
Causal ncRNA Number:210
Network:
Top Causal ncRNAs:
MALAT1  (Score: 1)
MALAT1  (Score: 1)
HOTAIR  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
circPPP1R12A  (Score: 0.985791)
CASC9  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//migration assay//Luciferase Report Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35034539
Disease Name:Colonic Neoplasms
Sample:COAD tissues
Dysfunction Pattern:Interaction(miR-515-5p/SLIT3 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//migration assay//Luciferase Report Assay//Cell Proliferation Assay
Description: The results showed that UBXN10-AS1 and SLIT3 were expressed at low levels in COAD tissues, while miR-515-5p was expressed at high levels. The luciferase reporter and RNA RIP assays demonstrated that UBXN10-AS1 targeted miR-515-5p, which in turn targeted SLIT3. Functionally, miR-515-5p overexpression reversed the inhibition of COAD cell proliferation and migration by UBXN10-AS1 overexpression, and SLIT3 overexpression counteracted the oncogenicity of miR-515-5p.
Causality:Yes
Causal Description:UBXN10-AS1 overexpression suppressed tumor growth in vitro and in vivo.
Clinical-realted Application: