Entry Detail

General Information

Database ID: LDA0005432
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PITPNA-AS1
Full Name:PITPNA antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:17
Strand:+
Coordinate:
Start Site(bp):1516919End Site(bp):1518096
External Links:
Ensembl ID:ENSG00000236618
Ensembl Transcript ID:N/A
Entrez Gene:100306951.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
lung squamous cell carcinoma  (Score: 0.985791)
lung squamous cell carcinoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Tunel//Flow Cytometry//qRT-PCR//FISH//CCK8//Luciferase Report Assay// In Vivo Experiment//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32871048
Disease Name:lung squamous cell carcinoma
Sample:LUSC samples,LUSC cells
Dysfunction Pattern:regulation[stabilizing HMGB3 by TAF15]
Validated Method:RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Description:Through online database GEPIA, lncRNA PITPNA antisense RNA 1 (PITPNA-AS1) was highly expressed in LUSC samples, and these tendency was further affirmed in LUSC cells. All in all, PITPNA-AS1 promoted the proliferation and migration of LUSC cells via stabilizing HMGB3 by TAF15.
Causality:Yes
Causal Description:Functional experiments verified that depletion of PITPNA-AS1 hampered the proliferative and migratory abilities, but accelerated apoptosis of LUSC cells.
Clinical-realted Application:

[2] PubMed ID:35588441
Disease Name:lung squamous cell carcinoma
Sample:LUSC tissues and cells
Dysfunction Pattern:Interaction(LncRNA PITPNA-AS1/miR-223-3p/PTN axis )
Validated Method:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay// In Vivo Experiment//Colony Formation Assay//Transwell Assay
Description:The lncRNA PITPNA-AS1 had increased expression in LUSC and was linked to a poor prognosis. This mechanistic investigation showed that PITPNA-AS1 absorbed miR-223-3p and that miR-223-3p targeted PTN. MiR-223-3p inhibition or PTN overexpression might reverse the inhibitory effects of PITPNA-AS1 suppression on LUSC progression, as demonstrated by rescue experiments. In addition, the PITPNA-AS1/miR-223-3p/PTN axis accelerated tumor development in vivo.
Causality:Yes
Causal Description:In LUSC, PITPNA-AS1 also enhanced cell proliferation, migration, invasion, and stemness.
Clinical-realted Application:The lncRNA PITPNA-AS1 had increased expression in LUSC and was linked to a poor prognosis.